Evidence map›Paper›PMID 42737834›Full record

ReviewInternational journal of molecular sciences2026

The CAGE Framework (Calcium-Gated Excitability): From Single Neurotransmitters to Calcium States in the Tumor Microenvironment.

Lena M Rudy, Michał M Godlewski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lena M RudyScientific Society of Veterinary Medicine Students, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.ORCID 0009-0004-0163-1055
Michał M GodlewskiDepartment of Physiological Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.ORCID 0000-0002-5479-207X

Funding

Warsaw University of Life Sciences
6 · The paper itself

Abstract

The tumor microenvironment (TME) is an innervated and neurochemically active setting. To date, its cholinergic and GABAergic signaling have largely been analyzed as separate systems, contributing to inconsistent findings across the literature. We propose a Calcium-Gated Excitability (CAGE) model, in which α7 nicotinic acetylcholine receptor (nAChR), α4β2 nAChR, GABA type A (GABA

Indexed as

CalciumNeoplasmsNeurotransmitter AgentsTumor MicroenvironmentAnimalsCalcium Signalinggamma-Aminobutyric AcidHumansReceptors, GABA-AReceptors, NicotinicCalciumgamma-Aminobutyric AcidNeurotransmitter AgentsReceptors, GABA-AReceptors, NicotinicCACNA2D1Calcium-Gated Excitabilitycalcium signalingcancer neuroscienceGABAergic signalingnicotinic acetylcholine receptorstumor microenvironmentα2δ-1

Identifiers

PMID42737834
PMCPMC13565833

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.