ArticleInternational journal of molecular sciences2026
Microparticles Expressing IL-1β Are Linked to Neuroinflammation and Cognitive Decline After Carbon Monoxide Poisoning.
Awadhesh K Arya, Kinjal Sethuraman, Jaylyn Waddell, Abid R Bhat, Zuha Imtiyaz, Deepa Walia, Yuanyuan Liang, Yong Sung Cha, Yoonsuk Lee, Siamak Moayedi and 2 more
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Awadhesh K AryaDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-2142-4924 Kinjal SethuramanDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jaylyn WaddellDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Abid R BhatDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Zuha ImtiyazDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Deepa WaliaDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yuanyuan LiangDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yong Sung ChaDepartment of Emergency Medicine and Research, Institute of Hyperbaric Medicine and Science, Yonsei University Wonju College of Medicine, Wonju 26426, Republic of Korea.ORCID 0000-0001-9897-4273 Yoonsuk LeeDepartment of Emergency Medicine and Research, Institute of Hyperbaric Medicine and Science, Yonsei University Wonju College of Medicine, Wonju 26426, Republic of Korea.ORCID 0000-0003-0404-7255 Siamak MoayediDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0001-8168-2776 Douglas SwardDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Stephen R ThomDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-3533-6124 Funding
Inflammatory changes and glymphatic dysfunction in carbon monoxide neuropathologyR01NS122855 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI STEPHEN RAYMOND THOM · 2022 to 2026
$2.9MNINDS NIH HHS R01 NS122855NINDS NIH HHS R01-NS-122855Office of Naval Research N00014-22-1-2818
6 · The paper itselfAbstract
Immune mediators are elevated due to carbon monoxide (CO) poisoning but their role in the development of neurological deficits is unknown. Circulating microparticles (MPs) are elevated in response to CO and correlate with the development of neurological complications. We hypothesized that interleukin (IL)-1β is carried by MPs and contributes to the development of neurological sequelae (NS). Blood-borne IL-1β in CO-poisoned patients is almost exclusively carried by MPs. Healthy humans have 0.8 ± 0.8 (
Indexed as
Carbon Monoxide PoisoningCell-Derived MicroparticlesInterleukin-1betaNeuroinflammatory DiseasesAdultAnimalsFemaleHumansMaleMiceMiddle AgedInterleukin-1betacytokineextracellular vesiclesmicroparticlesneurodegenerationneurological sequelaeneutrophils
Identifiers
PMID42737777
PMCPMC13566203
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