Evidence map›Paper›PMID 42737733›Full record

ArticleInternational journal of molecular sciences2026

Photobiomodulation with 808 nm Laser Light Repairs Mitochondrial Integrity and Normalizes ROS, ATP, and Membrane Depolarization in Aβ-Exposed Primary Neurons in Alzheimer's Disease Model.

Iuliia Golovynska, Binjun Li, Qinglin Chen, Sergii Golovynskyi, Hao Xu, Yurii V Stepanov, Liudmyla I Stepanova, Fangrui Lin, Junle Qu, Tymish Y Ohulchanskyy

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Iuliia GolovynskaShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0003-3916-6588
Binjun LiShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Qinglin ChenShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0009-0005-8706-107X
Sergii GolovynskyiShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-1864-976X
Hao XuShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Yurii V StepanovR.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Science of Ukraine, 03022 Kyiv, Ukraine.ORCID 0000-0002-6349-631X
Liudmyla I StepanovaInstitute of Biology and Medicine, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Fangrui LinShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Junle QuShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0001-7833-4711
Tymish Y OhulchanskyyShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-7051-6534

Funding

Key Laboratory of Biomedical Optics Micro-Nano Detection and Imaging ZDSY20130329101226215National Natural Science Foundation of China W2431056, 62127819, T2421003, 62435011, 62475163, 62361136586Shenzhen Key Laboratory of Photonics and Biophotonics ZDSYS20210623092006020Shenzhen Science and Technology Innovation Commission JCYJ20220818100202005
6 · The paper itself

Abstract

Alzheimer's disease (AD) is increasingly recognized as a disorder involving profound mitochondrial dysfunction. Although photobiomodulation (PBM) has shown neuroprotective efficacy in experimental AD models, whether restoration of mitochondrial architecture is mechanistically required for these effects remains unknown. Here, we investigated the role of mitochondrial network remodeling in PBM-mediated neuroprotection in primary mouse hippocampal neurons exposed to amyloid-β (Aβ). Neurons were treated for 24 h with oligomeric Aβ

Indexed as

Adenosine TriphosphateAlzheimer DiseaseAmyloid beta-PeptidesLow-Level Light TherapyMitochondriaNeuronsReactive Oxygen SpeciesAnimalsCells, CulturedDisease Models, AnimalHippocampusMembrane Potential, MitochondrialMiceMitochondrial DynamicsPeptide FragmentsAdenosine TriphosphateAmyloid beta-PeptidesPeptide FragmentsReactive Oxygen SpeciesAlzheimer’s diseaseamyloid-βmitochondrial network morphologyneuronsphotobiomodulation

Identifiers

PMID42737733
PMCPMC13565913

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.