ArticleInternational journal of molecular sciences2026
Muscle Spindle Alterations Following Ischemic Stroke and Peripheral Denervation in Murine Models.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Proprioceptive dysfunction is a common rehabilitation issue in neurological injury, and the muscle spindle (MS) is considered a critical structure in this dysfunction. The present study aimed to investigate the morphological alterations of MS in two classical neurological diseases: denervation and stroke, and to understand the role of MS in these two diseases preliminarily. The denervation and stroke model animals were constructed by using a surgical operation and middle cerebral artery occlusion (MCAO) protocol, respectively. The muscles from the affected-side limb and the healthy-side limb were harvested and then fixed, embedded, sliced, stained, and subjected to other laboratory analysis at the predetermined time point. The capsule thickness, cross-sectional area (CSA) of intrafusal fiber and extrafusal fiber, the collagen area percentage, and the hyaluronic acid were investigated in the denervation and stroke animal model. In denervation rats, the capsule thickness in the denervation-side limb increased significantly with the
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