ArticleInternational journal of molecular sciences2026
Effects of Anesthesia Neurotoxicity on Oligodendrocyte Development and Myelination: An In Vitro Study Using Primary Cultures.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
General anesthesia allows safe and comfortable performance of surgical operations, but early-life general anesthetic (GA) exposure may cause harm to the developing brain. The mechanism for this phenomenon remains unclear. Laboratory models demonstrate a variety of effects of GA on the immature brain, but consequences of early-life anesthetic exposure on oligodendrocyte development have seldomly been reported. To better understand the potentially toxic effects of GA on brain development, this study uses oligodendrocyte progenitor cells (OPCs) from primary cultures to investigate the effects of isoflurane (ISO), a canonical inhaled GA, on oligodendrocyte development and myelination. OPCs from cerebral cortices of newborn mice (P3) were cultured and purified with the anti-O4 microbeads technique. More than 92% of cells were confirmed as OPCs. On day of in vitro (DIV) 4, OPCs were exposed to 1.5% ISO in carrier gas (5% CO
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