Evidence map›Paper›PMID 42737696›Full record

ArticleInternational journal of molecular sciences2026

Expression of the Human R163C-

Christopher D Barnhart, Rebecca J Wilson, Sunjay Sethi, Hao Chen, Kim M Truong, Izabela Kania-Korwel, Hans-Joachim Lehmler, Isaac N Pessah, Pamela J Lein

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher D BarnhartDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Rebecca J WilsonDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.ORCID 0000-0002-1032-7432
Sunjay SethiDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Hao ChenDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.ORCID 0000-0002-5129-4286
Kim M TruongDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Izabela Kania-KorwelDepartment of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.
Hans-Joachim LehmlerDepartment of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-9163-927X
Isaac N PessahDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Pamela J LeinDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.ORCID 0000-0001-7665-7584

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5M
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Jonathan London · 2015 to 2026
$26.0M
UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
Molecular and Cellular Basis of PCB Developmental Neurotoxicity: ViCTER supplementR01ES014901 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HANS-JOACHIM LEHMLER, Pamela J Lein · 2009 to 2026
$9.3M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
Enantioselective Metabolism Influences PCB Developmental NeurotoxicityR01ES017425 · NIEHS · UNIVERSITY OF IOWA · PI LEHMLER, HANS-JOACHIM, LEIN, PAMELA J · 2010 to 2014
$2.0M
EPA RD 83543201NIEHS NIH HHS P01 ES011269NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R01 ES014901NIEHS NIH HHS R01 ES017425NIEHS NIH HHS T32 ES007059
6 · The paper itself

Abstract

Epidemiological studies have identified the developing brain as a target of concern for polychlorinated biphenyls (PCBs). In animal models, behavioral deficits caused by developmental exposure to PCBs have been associated with altered patterns of dendritic arborization in functionally relevant brain regions. In vitro studies revealed that PCB 95 promoted dendritic growth in primary rat hippocampal neuron-glia co-cultures via ryanodine receptor 1 (RYR1)-dependent Ca

Indexed as

Neurotoxicity SyndromesPolychlorinated BiphenylsRyanodine Receptor Calcium Release ChannelAnimalsDendritesFemaleHumansMaleMaze LearningMiceMice, Inbred C57BLMutationPyramidal CellsWeaning2,2',3,5',6-pentachlorobiphenylPolychlorinated BiphenylsRyanodine Receptor Calcium Release Channelcalcium-dependent signalingneural exposomeneurodevelopmental disordersneuronal connectivitypolychlorinated biphenylsryanodine receptor

Identifiers

PMID42737696
PMCPMC13565785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.