ReviewInternational journal of molecular sciences2026
1,2-Benzothiazine Derivatives as Anti-HIV and Anti-HCV Agents: Structure-Activity Relationships and Research Perspectives.
Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
1,2-Benzothiazine derivatives have attracted attention as structurally versatile scaffolds for antiviral drug discovery. Their sulfur-containing heterocyclic core supports diverse substitution patterns, allowing modulation of physicochemical properties and biological activity through medicinal chemistry optimization. This review summarizes published studies on 1,2-benzothiazine-based derivatives as potential inhibitors of human immunodeficiency virus (HIV) and hepatitis C virus (HCV), with particular emphasis on structure-activity relationships (SAR). Comprehensive SAR analyses indicate that substitutions at the N-1 and C-3 positions play a pivotal role in modulating antiviral potency and selectivity. Among the reported compounds, the most selective anti-HIV agent was a pyrazole-substituted 1,2-benzothiazine (
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