Evidence map›Paper›PMID 42737661›Full record

ReviewInternational journal of molecular sciences2026

Unique Features of Melanoma Risk and Diagnosis in Red-Haired Populations.

Kiran R Ebrahimi, Stephen M Ostrowski, David E Fisher

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kiran R EbrahimiCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston 02129, MA, USA.ORCID 0009-0007-3222-7516
Stephen M OstrowskiCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston 02129, MA, USA.
David E FisherCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston 02129, MA, USA.

Funding

Transcriptional mechanisms and melanomaP01CA163222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID E FISHER · 2013 to 2026
$25.3M
The MITF transcriptional network: melanoma risk and carcinogenesisR01AR043369 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID E FISHER · 1996 to 2026
$9.4M
Therapeutic strategies for treatment of giant congenital melanocytic neviR01AR072304 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID E FISHER · 2017 to 2026
$3.9M
Department of Defense Melanoma Academy W81XWH2220052Dr. Miriam and Sheldon G. Adelson Medical Research FoundationNCI NIH HHS P01 CA163222NIAMS NIH HHS R01 AR043369NIAMS NIH HHS R01 AR072304NIH HHS 5P01CA163222-26NIH HHS 5R01AR072304-26Water Cove Charitable FoundationWigglesworth Professorship in Dermatology
6 · The paper itself

Abstract

Cutaneous melanoma is the most lethal skin cancer, and risk is strongly shaped by pigmentary phenotype. The red-hair color phenotype, marked by red hair, fair skin, freckling, and poor tanning, carries elevated melanoma risk driven largely by loss-of-function variants in the melanocortin 1 receptor gene (

Indexed as

Hair ColorMelanomaSkin NeoplasmsGenetic Predisposition to DiseaseHumansMelaninsPhenotypeReceptor, Melanocortin, Type 1MC1R protein, humanMelaninsReceptor, Melanocortin, Type 1amelanotic melanomaeumelaninMC1Rmelaninmelanomanevipheomelaninred-hair color phenotypeskin cancer screening

Identifiers

PMID42737661
PMCPMC13566574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.