Blood-Based Biomarkers for the Preterminal Stage Using Rhesus Macaques Exposed to Acute Total-Body Radiation.

Matthew W Brink, Alana D Carpenter, Rachel C Mingus, Sarah A Petrus, Oluseyi O Fatanmi, Stephen Y Wise, Vijay K Singh

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew W BrinkDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0009-0009-9361-3263

Alana D CarpenterDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-2108-2274

Rachel C MingusDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0009-0008-1729-5139

Sarah A PetrusDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0003-2645-7570

Oluseyi O FatanmiDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-7942-2497

Stephen Y WiseDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-7613-7455

Vijay K SinghDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-6631-3849

Funding

Defense Health Agency 75-13266Uniformed Services University of the Health Sciences 10650Uniformed Services University of the Health Sciences 12080Uniformed Services University of the Health Sciences 13586

6 · The paper itself

Abstract

Acute radiation syndrome is characterized by progressive hematologic decline and biochemical imbalances, yet the transition from recoverable injury to the preterminal state remains incompletely characterized using routine laboratory assays. Prior proteomic, metabolomic, and transcriptomic studies have revealed biological signatures in preterminal serum and plasma samples from irradiated nonhuman primates, suggesting that the preterminal state represents a distinct phenotype. In this study, complete blood count and serum biochemistry data collected from male and female rhesus macaques (

Indexed as

Acute Radiation SyndromeBiomarkersWhole-Body IrradiationAnimalsBlood Cell CountFemaleGamma RaysMacaca mulattaMaleBiomarkersacute radiation syndromebiomarkerscomplete blood countpreterminalrhesus macaquesserum chemistry

Identifiers

PMID42737606

DOI10.3390/ijms27177709

PMCPMC13565886

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.