Evidence map›Paper›PMID 42737602›Full record

ArticleInternational journal of molecular sciences2026

Comparative Effects of Flurbiprofen and Benzydamine on COX-2/PGE

Emmanuel Mfotie Njoya, Maria Spears, Thomas Hallett, Philippa Peters, Fiona Burke, Olumayokun A Olajide

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emmanuel Mfotie NjoyaDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK.ORCID 0000-0003-1163-7202
Maria SpearsReckitt Benckiser Health Limited, Dansom Lane, Hull HU8 7DS, UK.
Thomas HallettReckitt Benckiser Health Limited, Dansom Lane, Hull HU8 7DS, UK.ORCID 0009-0004-5258-3022
Philippa PetersReckitt Benckiser Health Limited, Dansom Lane, Hull HU8 7DS, UK.
Fiona BurkeReckitt Benckiser Health Limited, Dansom Lane, Hull HU8 7DS, UK.
Olumayokun A OlajideDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK.ORCID 0000-0002-9254-8334

Funding

Reckitt Benckiser Health Limited 0000
6 · The paper itself

Abstract

Topical non-steroidal anti-inflammatory drugs (NSAIDs) such as flurbiprofen and benzydamine may be used for the symptomatic relief of pharyngitis, triggered by infections. The onset and spectrum of anti-inflammatory activity of both drugs were compared in human tonsil (HTEpiC) and bronchial epithelial (BEAS-2B) cells stimulated with poly I:C against key inflammatory mediators. Cells were stimulated with poly I:C for 24 h and treated with flurbiprofen or benzydamine for 20 s, 2 min and 5 min. Production of prostaglandin E2 (PGE

Indexed as

BenzydamineBronchiCyclooxygenase 2CytokinesDinoprostoneEpithelial CellsFlurbiprofenPalatine TonsilAnti-Inflammatory Agents, Non-SteroidalCell LineHumansPoly I-CAnti-Inflammatory Agents, Non-SteroidalBenzydamineCyclooxygenase 2CytokinesDinoprostoneFlurbiprofenPoly I-CPTGS2 protein, humanbenzydaminechemokinesCOX-2cytokinesflurbiprofenPGE2pharyngitis

Identifiers

PMID42737602
PMCPMC13566911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.