Evidence map›Paper›PMID 42737588›Full record

ArticleInternational journal of molecular sciences2026

Macrophages as Drivers of Resistance to Dabrafenib Plus Trametinib Therapy in Anaplastic Thyroid Cancer.

Ricardo Rodrigues, Beatriz Garcia, Miguel Rito, Rúben Roque, Teresa Pereira, Sónia Morgado, Vanessa Tavares, Tiago Nunes da Silva, Valeriano Leite, Branca Maria Cavaco

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ricardo RodriguesUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Professor Lima Basto, 1099-023 Lisboa, Portugal.ORCID 0000-0003-1928-4106
Beatriz GarciaUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Professor Lima Basto, 1099-023 Lisboa, Portugal.ORCID 0009-0009-7771-5331
Miguel RitoServiço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Professor Lima Basto, 1099-023 Lisboa, Portugal.ORCID 0000-0002-0226-5905
Rúben RoqueServiço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Professor Lima Basto, 1099-023 Lisboa, Portugal.ORCID 0000-0003-2368-4516
Teresa PereiraServiço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Professor Lima Basto, 1099-023 Lisboa, Portugal.
Sónia MorgadoServiço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Professor Lima Basto, 1099-023 Lisboa, Portugal.
Vanessa TavaresServiço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Professor Lima Basto, 1099-023 Lisboa, Portugal.
Tiago Nunes da SilvaUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Professor Lima Basto, 1099-023 Lisboa, Portugal.
Valeriano LeiteUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Professor Lima Basto, 1099-023 Lisboa, Portugal.ORCID 0000-0001-5479-7332
Branca Maria CavacoUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Professor Lima Basto, 1099-023 Lisboa, Portugal.ORCID 0000-0001-8946-8635

Funding

Associação de Endocrinologia Oncológica (AEO)Associated Laboratory LS4FUTURE doi: 10.54499/LA/P/0087/2020Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino SuperioriNOVA4Health - Programme in Translational Medicine Unit UID/04462; UID/PRR/04462/2025 - https://doi.org/10.54499/UID/PRR/04462/2025iNOVA4Health Research Unit UIDP/04462/2020; UI/BD/154256/2022 (https://doi.org/10.54499/UI/BD/154256/2022)Instituto Português de Oncologia de Lisboa Francisco Gentil
6 · The paper itself

Abstract

Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy with poor response to standard therapies. While Dabrafenib plus Trametinib (DT) combination therapy has improved the survival of patients with

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsDrug Resistance, NeoplasmImidazolesMacrophagesOximesPyridonesPyrimidinonesThyroid Carcinoma, AnaplasticThyroid NeoplasmsCell Line, TumorCell SurvivalCoculture TechniquesHumansProto-Oncogene Proteins B-rafdabrafenibImidazolesOximesProto-Oncogene Proteins B-rafPyridonesPyrimidinonestrametinibanaplastic thyroid carcinomaDabrafenib plus TrametinibmacrophagesSPRY4

Identifiers

PMID42737588
PMCPMC13565890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.