Evidence map›Paper›PMID 42737562›Full record

ArticleInternational journal of molecular sciences2026

Targeting PKM2 Enhances the Anti-Tumor Function of CD8

Junxiu Zhang, Shuyi Wu, Qin Yin, Yanglin Liu, Shuguo Zheng, Peiwei Yang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junxiu ZhangSchool of Pharmacy, Wannan Medical University, 22 Wenchang West Road, Higher Education Park, Wuhu 241002, China.
Shuyi WuSchool of Pharmacy, Wannan Medical University, 22 Wenchang West Road, Higher Education Park, Wuhu 241002, China.
Qin YinSchool of Pharmacy, Wannan Medical University, 22 Wenchang West Road, Higher Education Park, Wuhu 241002, China.
Yanglin LiuSchool of Pharmacy, Wannan Medical University, 22 Wenchang West Road, Higher Education Park, Wuhu 241002, China.
Shuguo ZhengSchool of Pharmacy, Wannan Medical University, 22 Wenchang West Road, Higher Education Park, Wuhu 241002, China.
Peiwei YangSchool of Pharmacy, Wannan Medical University, 22 Wenchang West Road, Higher Education Park, Wuhu 241002, China.ORCID 0000-0002-8449-5551

Funding

Anhui Provincial University Natural Science Research Project 2024AH051882High-level Talent Scientific Research Startup Foundation of Wannan Medical College WYRCQD2025028National Natural Science Foundation of China 82302071Wuhu Science and Technology Plan Project 2025KJ059
6 · The paper itself

Abstract

The efficacy of adoptive cell transfer (ACT) therapy in solid tumors is often limited by the functional exhaustion and insufficient persistence of infused CD8

Indexed as

Carrier ProteinsCD8-Positive T-LymphocytesMelanoma, ExperimentalMembrane ProteinsThyroid HormonesAnimalsCell Line, TumorGlycolysisImmunotherapy, AdoptiveLymphocytes, Tumor-InfiltratingMetabolic ReprogrammingMiceMice, Inbred C57BLPhosphopyruvate HydratasePyruvate KinaseT-Cell ExhaustionCarrier ProteinsMembrane ProteinsPhosphopyruvate HydratasePkm protein, mousePyruvate KinaseThyroid Hormone-Binding ProteinsThyroid Hormonesadoptive cell transferCD8+ T cellsenolase 1glycolysismetabolic reprogramming

Identifiers

PMID42737562
PMCPMC13566760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.