Evidence map›Paper›PMID 42737514›Full record

ArticleInternational journal of molecular sciences2026

Long Noncoding RNAs (lncRNAs) as Biomarkers of Prognosis in TNBC and Non-TNBC Breast Cancer Patients.

Marcio Luis Acencio, Xinhui Wang, Flavia R Rotea Mangone, Dirce Maria Carraro, Andrea S Llera, Eliana S F W Abdelhay, Nora Artagaveytia, Adrian Daneri-Navarro, Eduardo Moraes Reis, Leonardo Sanches and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marcio Luis AcencioBioinformatics Core Unit, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362 Esch-sur-Alzette, Luxembourg.ORCID 0000-0002-8278-240X
Xinhui WangBioinformatics Core Unit, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362 Esch-sur-Alzette, Luxembourg.ORCID 0000-0001-8697-4209
Flavia R Rotea MangoneCentro de Investigação Translacional em Oncologia-CTO, Instituto do Câncer do Estado de Sao Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Avenida Doutor Arnaldo, 251, 8° Floor, Sao Paulo 01246-000, SP, Brazil.ORCID 0000-0002-1730-9931
Dirce Maria CarraroClinical and Functional Group, Centro Internacional de Pesquisa (CIPE), AC Camargo Cancer Center, Sao Paulo 01508-010, SP, Brazil.
Andrea S LleraMolecular and Cellular Therapy Laboratory, Fundación Instituto Leloir-CONICET, Buenos Aires C1405BWE, Argentina.ORCID 0000-0002-0089-0061
Eliana S F W AbdelhayBone Marrow Transplantation Unit, Instituto Nacional de Câncer, Rio de Janeiro 20230-130, RJ, Brazil.ORCID 0000-0001-5166-0832
Nora ArtagaveytiaHospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo 11600, Uruguay.ORCID 0000-0001-8798-7941
Adrian Daneri-NavarroDepartment of Cellular and Molecular Biology, Universidad de Guadalajara, Guadalajara 44430, Mexico.
Eduardo Moraes ReisComprehensive Center for Precision Oncology, Universidade de Sao Paulo, Avenida Doutor Arnaldo, 251, 8° Floor, Sao Paulo 01246-000, SP, Brazil.ORCID 0000-0002-9556-3070
Leonardo SanchesComprehensive Center for Precision Oncology, Universidade de Sao Paulo, Avenida Doutor Arnaldo, 251, 8° Floor, Sao Paulo 01246-000, SP, Brazil.
Roger ChammasCentro de Investigação Translacional em Oncologia-CTO, Instituto do Câncer do Estado de Sao Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Avenida Doutor Arnaldo, 251, 8° Floor, Sao Paulo 01246-000, SP, Brazil.ORCID 0000-0003-0342-8726
Osvaldo L PodhajcerMolecular and Cellular Therapy Laboratory, Fundación Instituto Leloir-CONICET, Buenos Aires C1405BWE, Argentina.
Carlos VelazquezUniversidad de Sonora, Hermosillo 83000, Mexico.ORCID 0000-0002-3728-7848
Maria A NagaiCentro de Investigação Translacional em Oncologia-CTO, Instituto do Câncer do Estado de Sao Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Avenida Doutor Arnaldo, 251, 8° Floor, Sao Paulo 01246-000, SP, Brazil.ORCID 0000-0002-0728-4937

Funding

FIC NIH HHS no grant number appliesMinistry of Health no grant number appliesNCI NIH HHS # HHSN2612010000871/NO2-PC-2010-00087Susan G. Komen Breast Cancer Foundation no grant number applies
6 · The paper itself

Abstract

Functional studies have shown that long noncoding RNAs (lncRNAs) play different roles in gene expression regulation, acting as epigenetic factors. Accumulating evidence indicates that lncRNAs modulate diverse biological processes, and their altered expression is associated with the development and progression of cancer, including BC. Here, aiming to identify lncRNAs associated with breast cancer, we performed a re-analysis of the expression data from 1071 tumors of eligible patients in the LACRN-MPBC Study. Using normalized data, we compared the expression profiles of triple-negative breast cancer (TNBC; 170 cases) and a heterogeneous group of non-TNBC tumors (782 cases). A total of 59 differentially expressed lncRNAs (DELncRNAs) could be identified based on the criteria of |log2FC| ≥ 1 and FDR < 0.05, using the DESeq2 R package. In the Kaplan-Meier survival analysis, we identified DELncRNAs that affect disease-free survival and/or overall survival, with eight of them in TNBC and 27 in non-TNBC patients. Multivariate Cox proportional-hazards models were used to evaluate independent predictors of survival. Two DELncRNAs,

Indexed as

Biomarkers, TumorBreast NeoplasmsRNA, Long NoncodingTriple Negative Breast NeoplasmsDisease-Free SurvivalFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimatePrognosisBiomarkers, TumorRNA, Long Noncodingbiomarkerbreast cancerEGOTlncRNAsPART1prognosticVLDLR-AS1

Identifiers

PMID42737514
PMCPMC13566564

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.