Evidence map›Paper›PMID 42737473›Full record

ArticleInternational journal of molecular sciences2026

Early Emergence of HDL Oxidation Across the Body Mass Index Spectrum in Patients with Suspected Coronary Artery Disease.

Benjamin Sasko, Tonghuan Shi, Martin Christ, Oliver Ritter, Sawa Kostin, Innas Sultana, Simin Delalat, Jörg Celesnik, Metin Senkal, Ibrahim El-Battrawy and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Benjamin SaskoRuhr-University Bochum, Marien Hospital Herne, Medical Department II, Hölkeskampring 40, 44625 Herne, Germany.
Tonghuan ShiDepartment of Cellular and Translational Physiology, Institute of Physiology, Molecular and Experimental Cardiology, Institut für Forschung und Lehre (IFL), Ruhr University Bochum, 44801 Bochum, Germany.
Martin ChristDepartment of Cardiology, Knappschaft Kliniken Bottrop, Academic Teaching Hospital, University Duisburg-Essen, 46242 Bottrop, Germany.ORCID 0000-0001-6435-5626
Oliver RitterDepartment of Cardiology, Medical School Theodor Fontane, University Medical Center Brandenburg an der Havel, 14770 Brandenburg an der Havel, Germany.
Sawa KostinFaculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus-Senftenberg, the (MHB) Theodor Fontane and the University of Potsdam, 14469 Potsdam, Germany.
Innas SultanaDepartment of Cellular and Translational Physiology, Institute of Physiology, Molecular and Experimental Cardiology, Institut für Forschung und Lehre (IFL), Ruhr University Bochum, 44801 Bochum, Germany.
Simin DelalatDepartment of Cellular and Translational Physiology, Institute of Physiology, Molecular and Experimental Cardiology, Institut für Forschung und Lehre (IFL), Ruhr University Bochum, 44801 Bochum, Germany.ORCID 0000-0002-2246-0812
Jörg CelesnikDepartment of General and Visceral Surgery, Knappschaft Klinik Bottrop, Academic Teaching Hospital, University Duisburg-Essen, 46242 Bottrop, Germany.
Metin SenkalDepartment of General and Visceral Surgery, Marien Hospital Witten, 58452 Witten, Germany.
Ibrahim El-BattrawyDepartment of Cellular and Translational Physiology, Institute of Physiology, Molecular and Experimental Cardiology, Institut für Forschung und Lehre (IFL), Ruhr University Bochum, 44801 Bochum, Germany.
Theodoros KelesidisDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-8463-3811
Christian UkenaRuhr-University Bochum, Marien Hospital Herne, Medical Department II, Hölkeskampring 40, 44625 Herne, Germany.
Nazha HamdaniDepartment of Cellular and Translational Physiology, Institute of Physiology, Molecular and Experimental Cardiology, Institut für Forschung und Lehre (IFL), Ruhr University Bochum, 44801 Bochum, Germany.
Nikolaos PagonasFaculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus-Senftenberg, the (MHB) Theodor Fontane and the University of Potsdam, 14469 Potsdam, Germany.ORCID 0000-0003-3226-8135

Funding

Selective Tuning of Stem Cell Extracellular Vesicles as a Novel Therapy for Age-related TendinopathyR43AG059501 · NIA · ZEN-BIO, INC. · PI BUEHRER, BENJAMIN M, LUDLOW, JOHN WILLIAM · 2018 to 2018
$222k
NIA NIH HHS R43 AG059501
6 · The paper itself

Abstract

Obesity, commonly defined by body mass index (BMI), promotes cardiovascular disease through chronic inflammation and oxidative stress, which impair high-density lipoprotein (HDL) function and favor oxidative modification. Oxidized HDL (HDLox) may link adiposity to cardiovascular risk. However, the association between BMI and HDLox across the adiposity spectrum remains unclear. We therefore examined this relationship in a Coronary-Suspected Cohort. This study included 1227 consecutive patients undergoing elective coronary angiography. Participants were stratified into five predefined BMI categories. HDLox was quantified using a validated fluorometric assay assessing HDL lipid peroxide content. Associations between BMI and HDLox were analyzed using univariable and multivariable linear regression across the full BMI range and within a restricted BMI interval (15-35 kg/m

Indexed as

Body Mass IndexCoronary Artery DiseaseLipoproteins, HDLObesityAgedFemaleHumansMaleMiddle AgedOxidation-ReductionOxidative StressRisk FactorsLipoproteins, HDLacute coronary syndromecardiometabolic functionHDL functionoxidative stressoxidized HDL

Identifiers

PMID42737473
PMCPMC13566137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.