Evidence map›Paper›PMID 42737452›Full record

ArticleInternational journal of molecular sciences2026

Synthetic Preimplantation Factor (sPIF)* Improves Survival and GI Function in Acute Lethal Radiation Syndrome in a Clinically Relevant Murine Model.

Roberto Calix, Jean H Wilson, Martin Mueller, Peter M Glazer, Daniel Zelterman, Michelle Deveaux, Caroline Zeiss, Arumugam R Jayakumar, Eytan R Barnea, Michael J Paidas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roberto CalixSection of Maternal Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, 333 Cedar Street, FMB 329, P.O. Box 208063, New Haven, CT 06520-8063, USA.
Jean H WilsonYale Women and Children's Center for Blood Disorders and Preeclampsia Advancement, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 310 Cedar Street, FMB 220, New Haven, CT 06520-8063, USA.
Martin MuellerDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 333 Cedar Street, FMB 337A, New Haven, CT 06520-8063, USA.ORCID 0000-0001-5594-0532
Peter M GlazerDepartment of Therapeutic Radiology, Yale School of Medicine, P.O. Box 208040, New Haven, CT 06520-8040, USA.ORCID 0000-0003-4525-5560
Daniel ZeltermanYale School of Public Health, 60 College Street, P.O. Box 208034, New Haven, CT 06510-3201, USA.ORCID 0000-0003-0711-8688
Michelle DeveauxYale School of Public Health, 60 College Street, P.O. Box 208034, New Haven, CT 06510-3201, USA.
Caroline ZeissDepartment of Comparative Medicine, Yale School of Medicine, P.O. Box 208016, New Haven, CT 06520-8016, USA.ORCID 0000-0003-1181-3544
Arumugam R JayakumarTamer Family Department of Obstetrics, Gynecology, and Reproductive Sciences, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite # 1154, Miami, FL 33136-2107, USA.ORCID 0009-0009-2115-7860
Eytan R BarneaTamer Family Department of Obstetrics, Gynecology, and Reproductive Sciences, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite # 1154, Miami, FL 33136-2107, USA.
Michael J PaidasYale Women and Children's Center for Blood Disorders and Preeclampsia Advancement, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 310 Cedar Street, FMB 220, New Haven, CT 06520-8063, USA.

Funding

Treatment of Acute Radiation Syndrome using PIF, a Natural Immune ModulatorR41AI120546 · NIAID · BIOINCEPT, LLC · PI PAIDAS, MICHAEL JOHN · 2015 to 2015
$298k
NIAID NIH HHS 1R41AI120546-01NIAID NIH HHS R41 AI120546
6 · The paper itself

Abstract

Ionizing radiation (IR) damage, whether intentional, accidental, or therapeutic, reverberates throughout the body. The FDA has approved the use of palliative care and leukocyte growth factors for hematologic depletion (H-ARS), but no treatments have been approved for gastrointestinal damage (GI-ARS). Synthetic PIF (sPIF) safely replicates endogenous PIF's preventative, reparatory, and regenerative effects. Specifically relevant for radiation-induced damage, sPIF reduces oxidative stress. Subcutaneous (SC) sPIF prevents LD100/30 mortality at 2 w post-treatment and restores GI function post-6Gy exposure (in mice). Daily SC sPIF for 14 d, starting 24 h post-LD85/40 (7.17 Gy) total-body ɣ-irradiation (TBI), increases survival 2.76-fold (14.7% (5/34) to 40.7% (24/59);

Indexed as

Acute Radiation SyndromeGastrointestinal TractRadiation-Protective AgentsAnimalsDisease Models, AnimalFemaleMaleMiceRadiation-Protective AgentsBioIncept, LLChematopoietic and gastrointestinal ARSNew York*Proprietaryradiation injurySynthetic Preimplantation Factor (sPIF*)therapy

Identifiers

PMID42737452
PMCPMC13566414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.