Neonatal 2'-Fucosyllactose Supplementation Modulates Exploratory Behavior and Hippocampal Synaptic Plasticity in Rats Through Gut Microbiota and Metabolic Remodeling.

Miao Yu, Jin Wang, Ruixin Kou, Bingye Xu, Weiqian Zhang, Ying Zhang, Jingmin Liu, Shuo Wang

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Miao YuTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.

Jin WangTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.ORCID 0000-0002-3312-8831

Ruixin KouTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.ORCID 0009-0005-1613-2360

Bingye XuTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.ORCID 0009-0003-3761-7506

Weiqian ZhangTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.

Ying ZhangTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.

Jingmin LiuTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.

Shuo WangTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.

Funding

Fundamental Research Funds for the Central Universities, Nankai University 63261094Natural Science Foundation of Tianjin City 24JCYBJC01770

6 · The paper itself

Abstract

2'-Fucosyllactose (2'-FL) represents a significant constituent within human milk oligosaccharides, and its benefits for intestinal health and neurodevelopment in infants and young children have been widely recognized. However, the mechanism by which 2'-FL influences early-life behavioral development through the gut-brain axis remains incompletely understood. In this study, we investigated the effects of neonatal 2'-FL supplementation on behavioral development in Sprague-Dawley (SD) rats and explored its potential microbiota-metabolite regulatory mechanisms. After 4 consecutive weeks of oral gavage beginning on postnatal day 2, rats receiving 2'-FL showed significantly increased average movement speed and central-area exploration time in the open field test. From a systemic perspective, 2'-FL lowered blood diamine oxidase (DAO) and D-lactic acid (D-LA) concentrations while elevating colonic mRNA levels of tight junction protein-related genes, consequently enhancing intestinal barrier stability. In addition, 16S rRNA sequencing showed that 2'-FL reshaped the gut microbiota structure and significantly enriched

Indexed as

2′-fucosyllactosebehavioral developmentgut–brain axisgut microbiotaneonatal nutrition

Identifiers

PMID42737394

DOI10.3390/foods15173151

PMCPMC13565205

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.