ArticlePolymers2026
Chitosan-Gellan Gum Nanoparticles for Antituberculosis Drug Encapsulation: Synthesis, Characterization and In Vitro Investigation.
Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pulmonary delivery of anti-tuberculosis drugs has emerged as a promising alternative for increasing local drug concentrations whilst minimising side effects. Natural polymers-polysaccharides capable of forming polyelectrolyte complexes (PECs) through electrostatic interactions-show great promise in this field. In this study, mucoadhesive chitosan-gellan gum nanoparticles were developed for the controlled release of isoniazid using the polyelectrolyte complex coacervation method. Parameters such as the chitosan-to-gellan gum ratio and the medium pH were investigated to achieve suitable particle size, polydispersity, surface charge, drug loading and encapsulation efficiency. The morphology of the produced nanoparticles was determined using transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA), which confirmed the formation of nanoscale spherical particles. The mucoadhesive properties were tested on ovine lung tissue using fluorescence retention analysis, whilst in vitro drug release was studied under physiological conditions. Antimycobacterial activity against
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