ArticleHealthcare (Basel, Switzerland)2026
Emotion-Regulation Difficulties and Skills in the Cross-Sectional Association Between Thyroid Function and Antenatal Distress in Hypothyroid Pregnancy.
Article in Healthcare (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThyroid dysfunction and emotion-regulation difficulties are each linked to antenatal distress but are rarely measured in the same women. We examined whether emotion regulation accounts for the cross-sectional association between thyroid biochemistry and antenatal distress in hypothyroid pregnancy.
methodsIn this single-center cross-sectional study, 360 pregnant women with hypothyroidism completed measures of emotion-regulation difficulties and skills and four distress measures at one antenatal visit, alongside thyroid testing. Exposures were standardized log thyroid-stimulating hormone (TSH) and free thyroxine (free T4); the outcome was a composite distress score. Parallel two-mediator models with covariate adjustment were fitted, and bias-corrected bootstrapping was used to estimate the indirect associations.
resultsHigher log TSH (total association 0.189, 95% confidence interval [CI] 0.108 to 0.272) and lower free T4 (-0.200, 95% CI -0.278 to -0.120) were associated with greater distress. Most of each association was statistically accounted for by emotion-regulation difficulties and skills; direct associations included zero. Apparent route-specific moderation by gestational week and by thyroid autoimmunity was not supported, because the two indices did not differ.
conclusionsMeasurement at a single visit leaves temporal ordering unidentified, so these findings decompose a cross-sectional association rather than demonstrate causal mediation; within that constraint they support assessing emotion regulation alongside thyroid monitoring and depression screening.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.