Evidence map›Paper›PMID 42736830›Full record

ReviewHealthcare (Basel, Switzerland)2026

Factors Associated with Treatment Burden in Older Adults with Multimorbidity and Implications for Potential Reduction Strategies: A Scoping Review.

Leandro Amato, Gianluca Ciccaglione, Noemi Giannetta, Emanuele Di Simone, Nicolò Panattoni, Sara Dionisi, Alessandra Improta, Sofia Taborri, Marco Di Muzio

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Healthcare (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leandro AmatoDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0009-0000-9934-242X
Gianluca CiccaglioneDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0009-0004-1648-0376
Noemi GiannettaDepartmental Faculty of Medicine, Saint Camillus International University of Health and Medical Sciences (UniCamillus), 00131 Rome, Italy.ORCID 0000-0003-4575-1898
Emanuele Di SimoneDepartment of Medical, Movement and Wellbeing Sciences, Parthenope University of Naples, 80133 Naples, Italy.ORCID 0000-0002-6373-8163
Nicolò PanattoniNursing Research Unit IFO, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0002-4162-937X
Sara DionisiNursing, Technical, Rehabilitation Department, DaTeR Azienda Unità Sanitaria Locale di Bologna, 40124 Bologna, Italy.ORCID 0000-0001-7933-8490
Alessandra ImprotaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0009-0001-0668-0321
Sofia TaborriDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0009-0004-1381-7949
Marco Di MuzioDepartment of Wellbeing, Health and Environmental Sustainability, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-2641-4044

Funding

Sapienza University of Rome RM123188E8E68581
6 · The paper itself

Abstract

backgroundTreatment Burden (TB) refers to the workload imposed on patients by healthcare-related tasks involved in the management of chronic conditions. Despite increasing evidence on this phenomenon, strategies for its reduction in older adults with multimorbidity remain poorly explored.

aimTo map the factors associated with treatment burden reported for older patients with multimorbidity and to derive implications for potential reduction strategies, regardless of the care setting.

methodsA scoping review was conducted applying the JBI methodology for scoping reviews and reported in accordance with the PRISMA-ScR checklist. The literature search was performed on PubMed, Scopus, and CINAHL; no restrictions on publication year or language were applied. All study designs were eligible if they reported factors associated with TB from which reduction strategies could be derived, in patients aged ≥65 years, or with a mean age ≥ 65 years, with multimorbidity or associated geriatric conditions.

resultsSix studies met the eligibility criteria, all of which were observational in design, conducted between 2021 and 2025. Eleven potential strategies for TB reduction, inferred from observational findings, were identified and grouped into three areas: healthcare system and access to care, therapeutic regimen, and patient and psychosocial context.

conclusionsTo our knowledge, this review provides the first structured mapping of potential TB reduction strategies specifically in the older population with multimorbidity. The identified strategies, derived by the authors rather than empirically tested, may exclusively inform the design of future interventional studies and offer healthcare professionals preliminary guidance for TB management in this population.

Indexed as

deprescribingmedication adherencemultimorbidityolder adultsscoping reviewtreatment burden

Identifiers

PMID42736830
PMCPMC13564641

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.