ArticleMedicine2026
Association between Helicobacter pylori infection and rheumatoid arthritis: Results from the NHANES 1999-2000 and a Mendelian randomization study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
The relationship between Helicobacter pylori infection and rheumatoid arthritis (RA) remains controversial. Our study aimed to provide evidence regarding the association between H pylori infection and RA by analyzing data from the 1999 to 2000 National Health and Nutrition Examination Survey (NHANES) and conducting Mendelian randomization (MR) analyses. A weighted logistic regression analysis was performed to examine the relationship between H pylori infection and RA, utilizing data from NHANES for the years 1999 to 2000. Furthermore, a bidirectional MR analysis was executed to explore both the causal and reverse causal relationships between H pylori infection and seropositive as well as seronegative RA. The primary analysis utilized inverse variance weighted in conjunction with additional MR methodologies to corroborate the causal link between H pylori infection and RA. Additionally, assessments of heterogeneity, pleiotropy, and sensitivity analyses were conducted to evaluate the robustness of the results. The cross-sectional observational analysis and MR study did not provide clear evidence to support a correlation and causal relationship between H pylori infection and RA. A total of 550 participants were enrolled in our observational study in NHANES. Following the adjustment for various confounding variables, the analysis revealed no statistically significant association between H pylori infection and RA (odds ratio = 1.300; 95% confidence interval = 0.784-2.154, P = .416) . In the MR analysis, 7 common serum H pylori antibodies (anti-H pylori immunoglobulin G, GroEL, OMP, UREA, CagA, VacA, and Catalase) were not found to have a causal relationship with either seropositive or seronegative RA. Moreover, reverse MR analysis did not suggest a causal effect of seropositive or seronegative RA on H pylori infection. Results were robust across all sensitivity analyses.
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