ArticleBMC ophthalmology2026
Risk factor profiles and visual outcomes of non-arteritic anterior ischemic optic neuropathy in younger Chinese patients.
Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-arteritic anterior ischemic optic neuropathy (NAION) predominantly affects the elderly, although onset before age 50 is not uncommon. Systemic vascular diseases are the main risk factors in elderly patients, whereas ocular structural abnormalities may be associated with early-onset NAION. This study compared risk factor profiles and visual outcomes between young NAION patients and a selected contemporary comparison group of older patients consisting of consecutively enrolled cases within a predefined study period in China, to assess age-related differences.
methodsIn this single-center retrospective cohort study, patients diagnosed with NAION enrolled between May 2022 and February 2026 were stratified into a young group (aged < 50 years, n = 102) and a selected contemporary comparison group of older patients (aged ≥ 50 years, n = 111). Crucially, this older comparison group comprised consecutively enrolled cases within this predefined study period, rather than representing a random sample of all eligible older NAION patients. All patients underwent 6-month follow-up. Demographic, systemic, and ocular data, including best-corrected visual acuity (BCVA), visual field index (VFI), mean deviation (MD), and pattern standard deviation (PSD), were collected. Intergroup and intragroup comparisons were performed, and multivariable linear regression using a hybrid selection strategy (mandatory clinical covariates plus univariate screening) identified independent predictors of visual recovery.
resultsThe young group included more males, had fewer bilateral cases, and exhibited higher smoking rates compared with this older comparison cohort (all P < 0.05). Conversely, this older comparison cohort had a higher prevalence of hypertension, cardiovascular disease, and peripapillary hyperreflective ovoid mass-like structure (PHOMS) (all P < 0.05). Inferior hemifield defects predominated in young patients, whereas diffuse defects were more common in this older comparison cohort. Significant within-group improvements in BCVA, VFI, MD and PSD were observed only in the young group (all P < 0.01), with between-group differences reaching significance only for MD. Multivariable analysis showed that younger age, shorter onset-to-presentation time, and better baseline BCVA were factors associated with greater BCVA recovery, though these associations should be interpreted cautiously given study limitations.
conclusionsYounger and older NAION patients exhibit distinct risk profiles and visual field defect patterns. While younger patients demonstrated significant within-group visual improvement, only the change in mean deviation (MD) differed significantly between groups, necessitating cautious interpretation of age-related recovery differences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.