Evidence map›Paper›PMID 42736457›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Development and validation of a preoperative

Jiajia Hu, Hangxing Chunyu, Yihong Yang, Yanyan Song, Chao Cheng, Hailang Tang, Xiaoyue Chen, Ran Cheng, Jun Dai, Hongping Meng and 3 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06604377 (Model of Predicting Biochemical Recurrence After Radical Prostate Cancer Based on Pre-treatment PSMA PET / MR Image Features), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06604377 completednot on this map

Model of Predicting Biochemical Recurrence After Radical Prostate Cancer Based on Pre-treatment PSMA PET / MR Image Features

TypeobservationalSponsorRuijin HospitalRan2023 to 2024Enrolled203ConditionsProstate CancerArmsObserve
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiajia Hu *Department of Nuclear Medicine & Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Hangxing Chunyu *Department of Nuclear Medicine & Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Yihong Yang *Department of Nuclear Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Yanyan Song *Department of Biostatistics, Institute of Clinical Medicine, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China.
Chao ChengDepartment of Nuclear Medicine, Changhai Hospital, Navy Military Medical University, Shanghai, 200433, China.
Hailang TangDepartment of Ultrasound, Jiading North Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Xiaoyue ChenDepartment of Nuclear Medicine & Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Ran ChengDepartment of Nuclear Medicine & Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Jun DaiDepartment of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Hongping MengDepartment of Nuclear Medicine & Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Changjing ZuoDepartment of Nuclear Medicine, Changhai Hospital, Navy Military Medical University, Shanghai, 200433, China. changjing.zuo@qq.com.
Jun ZhaoDepartment of Nuclear Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. petcenter@126.com.
Biao LiDepartment of Nuclear Medicine & Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. lb10363@rjh.com.cn.ORCID http://orcid.org/0000-0002-0493-2062

Funding

hanghai Pujiang Program 21PJD042Longhua Hospital Shanghai University of Traditional Chinese Medicine No. SHDC12023103National Natural Science Foundation of China 82171976Shanghai Municipal Youth Science and Technology Star Project Shanghai Municipal Youth Science and Technology Star Project
6 · The paper itself

Abstract

purposeTo develop and externally validate a preoperative

methodsThis multicentre retrospective study included 210 patients from three centres (training, n = 150; external validation, n = 60). Predictors were selected by 10-fold cross-validated LASSO-Cox regression using the one-standard-error criterion and entered into a multivariable Cox model. Performance at 1-3 years was assessed using time-dependent AUCs, calibration, IPCW Brier scores, and decision-curve analysis. Incremental value beyond CAPRA-S was evaluated using likelihood-ratio tests (LRTs). Sensitivity analyses assessed the potential influence of persistent postoperative PSA and secondary treatment initiated before BCR.

resultsSeventy-five patients experienced the study endpoint of biochemical recurrence. The final model included ADCmin-TBR, TMR, and PET/MR T-stage. Time-dependent AUCs were 0.703-0.858 in the training cohort and 0.766-0.846 in the validation cohort. DeLong tests showed no significant AUC differences from CAPRA-S; however, adding the PET/MR model improved fit at 2 and 3 years in the derivation cohort (both LRT p < 0.001) and at 3 years in the external validation cohort (LRT p = 0.031). DCA showed positive net benefit across most clinically relevant thresholds. ADCmin-TBR and TMR remained directionally stable across sensitivity analyses, whereas the T-stage effect was attenuated after treatment censoring.

conclusionsThe

trial registrationClinicalTrials.gov (NCT06604377) retrospectively registered on September 17, 2024.

Indexed as

18F-PSMA-1007Biochemical recurrencePET/MRPrognostic modelProstate cancer

Identifiers

PMID42736457

What OpenQuestion holds

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Registered trials

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