Evidence map›Paper›PMID 42736367›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Endocannabinoid metabolism at VTA GABAergic neurons gates motivation for social, but not food, reward.

Carlos Medina-Saldivar, Carlos F Cardozo, Iness Gildish, Nana Baidoo, Ramesh Chandra, Miguel A Luján, Mary Kay Lobo, Marco Venniro, Joseph F Cheer

Abstract read
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In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carlos Medina-SaldivarDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Carlos F CardozoDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Iness GildishDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Nana BaidooDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Ramesh ChandraDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Miguel A LujánDepartment of Anatomy & Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-4195-1764
Mary Kay LoboDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9419-2079
Marco VenniroDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7653-957X
Joseph F CheerDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA. JCheer@som.umaryland.edu.ORCID http://orcid.org/0000-0001-5086-7559

Funding

U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA022340U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA060209U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA063051
6 · The paper itself

Abstract

The endocannabinoid system functions as a gatekeeper of motivational processes. Here, we show that CRISPR-mediated inhibition of the degrading enzyme for the brain endocannabinoid, 2-AG, at ventral tegmental area GABAergic interneurons promotes social, but not food-maintained, operant responding. These results reveal a region-specific role for endocannabinoid signaling in social motivation.

Identifiers

PMID42736367

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.