Evidence map›Paper›PMID 42736180›Full record

ArticlePoultry science2026

Multi-omics analyses reveal steroid hormone and antioxidant pathways regulating sperm storage capacity in female Muscovy ducks (Cairina moschata).

Zhou Wu, Xiaohuan Chao, Zhiqiang Chang, Liming Lan, Xue Rong Ma, Weijian Zhu, Aijun Liu, Weiming Liang, Xiquan Zhang, Cheng Fang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhou WuCollege of Animal Science, South China Agricultural University, Guangzhou, China; State Key Laboratory of Livestock and Poultry Breeding, South China Agricultural University, Guangzhou, China.
Xiaohuan ChaoCollege of Animal Science, South China Agricultural University, Guangzhou, China; State Key Laboratory of Livestock and Poultry Breeding, South China Agricultural University, Guangzhou, China.
Zhiqiang ChangCollege of Animal Science, South China Agricultural University, Guangzhou, China; State Key Laboratory of Livestock and Poultry Breeding, South China Agricultural University, Guangzhou, China.
Liming LanWens Foodstuff Group Co., Ltd., Xinxing, Yunfu, Guangdong, China.
Xue Rong MaWens Foodstuff Group Co., Ltd., Xinxing, Yunfu, Guangdong, China.
Weijian ZhuWens Foodstuff Group Co., Ltd., Xinxing, Yunfu, Guangdong, China.
Aijun LiuCollege of Animal Science, South China Agricultural University, Guangzhou, China; State Key Laboratory of Livestock and Poultry Breeding, South China Agricultural University, Guangzhou, China.
Weiming LiangCollege of Animal Science, South China Agricultural University, Guangzhou, China; State Key Laboratory of Livestock and Poultry Breeding, South China Agricultural University, Guangzhou, China.
Xiquan ZhangCollege of Animal Science, South China Agricultural University, Guangzhou, China; State Key Laboratory of Livestock and Poultry Breeding, South China Agricultural University, Guangzhou, China.
Cheng FangCollege of Engineering, South China Agricultural University, Guangzhou, China.
Congliang JiWens Foodstuff Group Co., Ltd., Xinxing, Yunfu, Guangdong, China. Electronic address: 34954584@qq.com.
Qingbin LuoCollege of Animal Science, South China Agricultural University, Guangzhou, China. Electronic address: qbluo@scau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The duration of fertility in poultry is directly influenced by sperm store ability within specialized sperm storage tubules (SSTs) of the female uterovaginal junction (UVJ). Improving the duration of fertility reduces artificial insemination frequency, influencing animal welfare, and production costs. Here, we investigated physiological and multi-omic factors underlying sperm storage capacity in female Muscovy ducks (Cairina moschata). Phenotypes were collected from approximately 1,500 ducks for three generations, with focus on the peak and late laying stages. High and low sperm storage individuals were classified for histological evaluation and multi-omics analyses (transcriptomics, proteomics, and metabolomics). Results show sperm storage capacity significantly declines with age, associated with ciliated cell integrity in the UVJ microenvironment. Multi-omics revealed enrichment in pathways, including steroid hormone biosynthesis, glutathione metabolism, and tryptophan metabolism. Metabolites such as cholesterol and progesterone were identified as potential biomarkers. Down-regulation of LIMA1 and CYP2R1, along with altered functional pathways, suggests coordinated regulation of antioxidation balance, immune response, and steroid synthesis within the UVJ microenvironment. Our findings provide a multi-omics framework for better understanding fertility duration and offer biomarker candidates and pathways for future genetic improvement in poultry reproduction.

Indexed as

Duration of fertilityMuscovy duckSperm storageUVJ

Identifiers

PMID42736180
PMCPMC13594959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.