Evidence map›Paper›PMID 42736025›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Molecular Disambiguation of Heart Rate Control by the Nucleus Ambiguus.

Maira Jalil, Mary Katherine MacMillan, Tatiana C Coverdell, Veronica A Gutierrez, Maisie E Crook, Travis J Heinrichs, Ashlyn Dever, Katie Shouse Cox, Daniel S Stornetta, Yoko B Wang and 6 more

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cardiac vagal motor neurons.Current opinion in neurobiology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Maira JalilDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Mary Katherine MacMillanNeuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22903.
Tatiana C CoverdellDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22903.
Veronica A GutierrezDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Maisie E CrookDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Travis J HeinrichsDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Ashlyn DeverDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Katie Shouse CoxDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Daniel S StornettaDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22903.ORCID https://orcid.org/0000-0002-5570-6276
Yoko B WangDalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211.
Dana C SchwalbeDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Adriana SinghDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Lane VanderVoortDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Carie R BoychukDalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211.
Stephen B G AbbottNeuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22903.ORCID https://orcid.org/0000-0003-1244-3637
John N CampbellDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904 jnc4e@virginia.edu.ORCID https://orcid.org/0000-0002-3943-8312

Funding

Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
P&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Deborah J Wexler · 2023 to 2026
$5.4M
Molecular and Functional Taxonomy of Cardiovagal NeuronsR01HL153916 · NHLBI · UNIVERSITY OF VIRGINIA · PI CAMPBELL, JOHN NELSON · 2021 to 2025
$3.1M
Unraveling Cardiovagal Circuits for Heart Rate with Molecular ConnectomicsR01HL188399 · NHLBI · UNIVERSITY OF VIRGINIA · PI John Nelson Campbell · 2026 to 2026
$722k
Unraveling Neural Circuits for Body Weight Control with Molecular ConnectomicsR01DK147947 · NIDDK · UNIVERSITY OF VIRGINIA · PI John Nelson Campbell · 2026 to 2026
$717k
Identification of cell-type specific visual circuits in the ventral lateral geniculate nucleusR21EY033528 · NEI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CAMPBELL, JOHN N, FOX, MICHAEL A · 2022 to 2023
$441k
NEI NIH HHS R21 EY033528NHLBI NIH HHS R01 HL153916NHLBI NIH HHS R01 HL188399NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK147947
6 · The paper itself

Abstract

The nucleus ambiguus (nAmb) provides parasympathetic control of cardiorespiratory functions as well as motor control of the upper airways and esophagus. A subset of nAmb neurons innervates the heart through the vagus nerve to control cardiac function at rest and during key autonomic reflexes such as the mammalian diving reflex. Yet, how these cardiovagal nAmb neurons differ from other nAmb neurons in the adult brain remains unclear. We therefore classified adult male and female mouse nAmb neurons molecularly, anatomically, and functionally. First, our integrated analysis of single-nucleus RNA-sequencing data predicted multiple molecular subtypes of nAmb neurons. Mapping the axon projections of one nAmb neuron subtype,

Indexed as

Heart RateMedulla OblongataNeuronsAnimalsFemaleMaleMiceMice, Inbred C57BLReceptors, Neuropeptide YVagus NerveReceptors, Neuropeptide Ycardiovagal neuronsdiving reflexheart rate regulationnucleus ambiguusparasympathetic nervous systemsingle-cell RNA-sequencingvagus nerve

Identifiers

PMID42736025
PMCPMC13689988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.