ArticleInternational journal of urology : official journal of the Japanese Urological Association2026
Distinct Predictors of Early Postoperative and Long-Term Renal Function Decline Following Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma.
Article in International journal of urology : official journal of the Japanese Urological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThis study aimed to evaluate early postoperative and long-term changes in renal function following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) and to identify factors associated with each phase.
methodsWe retrospectively reviewed 168 patients who underwent RNU for UTUC between 2007 and 2022. Renal function was assessed using estimated glomerular filtration rate (eGFR). Early postoperative renal function decline (RFD) was defined as the percentage decrease in eGFR from preoperative values to 1 month post-surgery. Factors associated with early postoperative RFD were evaluated using multivariable linear regression analyses. Long-term RFD was assessed using serial eGFR measurements obtained from 1 month after surgery onward and was analyzed with multivariable linear mixed-effects models.
resultsThe median follow-up period was 74.5 months. The median preoperative eGFR and early postoperative RFD were 53.1 mL/min/1.73m
conclusionsPredictors of early postoperative RFD differed from those of progressive long-term RFD following RNU. These findings suggest that early and long-term postoperative renal functional changes may need to be considered separately in clinical decision-making and patient counseling.
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