ArticleCirculation2026
SGLT2 Inhibitor Empagliflozin Reduces Circulating Monocyte-Platelet Aggregates: A Pilot Study.
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Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
31 authors.
B Ilkin Safa *Department of Medicine, Division of Diabetes, Endocrinology and Metabolism (B.I.S., Z.H., M.S.G., A.M., L.Z., W.H., M.M.), Vanderbilt University Medical Center, Nashville, TN.
Jared M Oakes *Department of Pathology, Microbiology, and Immunology (J.M.O., J.C.R., S.A.K.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-3910-1346
Joshua D SimmonsDepartment of Medicine, Division of Infectious Diseases (J.D.S., L.A.K., E.C.O., C.M.W., S.S.B., C.N.W., J.R.K., S.A.K.), Vanderbilt University Medical Center, Nashville, TN.
Hui NianDepartment of Biostatistics (H.N., Q.S.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-0047-8330
Leslie A KirkDepartment of Medicine, Division of Infectious Diseases (J.D.S., L.A.K., E.C.O., C.M.W., S.S.B., C.N.W., J.R.K., S.A.K.), Vanderbilt University Medical Center, Nashville, TN.
Anna C CassidyDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN (A.C.C.).ORCID 0000-0002-5171-9002
Eric C OlsonDepartment of Medicine, Division of Infectious Diseases (J.D.S., L.A.K., E.C.O., C.M.W., S.S.B., C.N.W., J.R.K., S.A.K.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-3642-8020
Zaid HatemDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism (B.I.S., Z.H., M.S.G., A.M., L.Z., W.H., M.M.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0009-0009-7716-2845
Christian M WarrenDepartment of Medicine, Division of Infectious Diseases (J.D.S., L.A.K., E.C.O., C.M.W., S.S.B., C.N.W., J.R.K., S.A.K.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0009-0007-5724-9092
Matthew S GonzalezDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism (B.I.S., Z.H., M.S.G., A.M., L.Z., W.H., M.M.), Vanderbilt University Medical Center, Nashville, TN.
Taneem AminDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine (T.A., M.T.S., E.M.W., K.N.C.), Vanderbilt University Medical Center, Nashville, TN.
Quanhu ShengDepartment of Biostatistics (H.N., Q.S.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-8951-9295
Anveetha MattaDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism (B.I.S., Z.H., M.S.G., A.M., L.Z., W.H., M.M.), Vanderbilt University Medical Center, Nashville, TN.
Lyndon ZhuDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism (B.I.S., Z.H., M.S.G., A.M., L.Z., W.H., M.M.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0009-0005-6020-2039
Walid HairanDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism (B.I.S., Z.H., M.S.G., A.M., L.Z., W.H., M.M.), Vanderbilt University Medical Center, Nashville, TN.
Sara E HowardDepartment of Medicine, Division of Clinical Pharmacology (S.E.H., J.M.L.), Vanderbilt University Medical Center, Nashville, TN.
C Robb FlynnDepartment of Surgery (C.R.F.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-3749-0598
Matthew T StierDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine (T.A., M.T.S., E.M.W., K.N.C.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-3928-1682
Erin M WilfongDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine (T.A., M.T.S., E.M.W., K.N.C.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-6584-1578
Jeffrey C RathmellDepartment of Pathology, Microbiology, and Immunology (J.M.O., J.C.R., S.A.K.), Vanderbilt University Medical Center, Nashville, TN.
Katherine N CahillDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine (T.A., M.T.S., E.M.W., K.N.C.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-8549-1835
Jonathan D BrownDepartment of Medicine, Division of Cardiovascular Medicine (J.D.B., J.E.F.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-0359-6167
Joshua A BeckmanDivision of Vascular Medicine, University of Texas Southwestern Medical Center, Dallas (J.A.B.).ORCID 0000-0001-8332-8439
Curtis L GabrielDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition (C.L.G.), Vanderbilt University Medical Center, Nashville, TN.
Jane E FreedmanDepartment of Medicine, Division of Cardiovascular Medicine (J.D.B., J.E.F.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-0011-6164
J Matthew LutherDepartment of Medicine, Division of Clinical Pharmacology (S.E.H., J.M.L.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-7225-2897
Samuel S BailinDepartment of Medicine, Division of Infectious Diseases (J.D.S., L.A.K., E.C.O., C.M.W., S.S.B., C.N.W., J.R.K., S.A.K.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-4990-1013
Celestine N WanjallaDepartment of Medicine, Division of Infectious Diseases (J.D.S., L.A.K., E.C.O., C.M.W., S.S.B., C.N.W., J.R.K., S.A.K.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-9159-5414
John R KoetheDepartment of Medicine, Division of Infectious Diseases (J.D.S., L.A.K., E.C.O., C.M.W., S.S.B., C.N.W., J.R.K., S.A.K.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-6490-6942
Spyros A KalamsDepartment of Pathology, Microbiology, and Immunology (J.M.O., J.C.R., S.A.K.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-0098-7995
Mona MashayekhiDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism (B.I.S., Z.H., M.S.G., A.M., L.Z., W.H., M.M.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-0331-2395
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MVanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MTennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MInstitutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3MVANTAGE:Consolidation to create the Vanderbilt Technologies for Advanced GenomicsG20RR030956 · NCRR · VANDERBILT UNIVERSITY · PI PIETENPOL, JENNIFER A · 2010 to 2010
$8.7MInterdisciplinary Training Program in Lung ResearchT32HL094296 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ray Stokes Peebles · 2008 to 2026
$6.3MSingle cell molecular analysis of influenza vaccine responses in elderly individualsR01AI142095 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KALAMS, SPYROS A · 2019 to 2023
$2.9MGLP-1R agonist immune targets in lean and obesity-associated asthmaR01AI182159 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Katherine N Cahill · 2024 to 2026
$2.6MThe Effect of SGLT2 Inhibition on Adipose Tissue Inflammation and Endothelial FunctionK23HL159351 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Mona Mashayekhi · 2023 to 2026
$742kNCATS NIH HHS KL2 TR002245NCATS NIH HHS UL1 TR002243NCI NIH HHS P30 CA068485NCRR NIH HHS G20 RR030956NCRR NIH HHS UL1 RR024975NEI NIH HHS P30 EY008126NHLBI NIH HHS K23 HL159351NHLBI NIH HHS T32 HL094296NIAID NIH HHS P30 AI110527NIAID NIH HHS R01 AI142095NIAID NIH HHS R01 AI182159NIDDK NIH HHS P30 DK058404
Abstract
PubMed holds no abstract for this paper.
Indexed as
empagliflozininflammationmonocytesobesityprediabetic state
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.