Evidence map›Paper›PMID 42735020›Full record

ArticleeLife2026

Acyl carrier protein is essential for apicoplast biogenesis in malaria parasites independent of fatty acid synthesis.

Sage W R Geher, Seyi Falekun, Jessica N Pita-Aquino, Russell P Swift, Megan Okada, Yasaman Jami-Alahmadi, James A Wohlschlegel, Sean T Prigge, Paul A Sigala

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sage W R Geher *Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
Seyi Falekun *Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
Jessica N Pita-Aquino *Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID https://orcid.org/0000-0002-4333-214X
Russell P SwiftDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, United States.
Megan OkadaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID https://orcid.org/0000-0003-4398-9819
Yasaman Jami-AlahmadiDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0001-8289-2222
James A WohlschlegelDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, United States.
Sean T PriggeDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, United States.ORCID https://orcid.org/0000-0001-9684-1733
Paul A SigalaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID https://orcid.org/0000-0002-3464-3042

Funding

Proteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6M
Training Program in Microbial PathogenesisT32AI055434 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A, PLANELLES, VICENTE · 2004 to 2025
$6.0M
Determinants of apicoplast maintenance in malaria parasitesR01AI125534 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Sean Taylor PRIGGE · 2016 to 2026
$3.9M
Understanding Ubiquitin-dependent Regulation of Iron Metabolism using Mass SpectrometryR35GM153408 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Akira Wohlschlegel · 2024 to 2026
$1.2M
Molecular and Metabolic Adaptations of Intracellular ParasitismR35GM161383 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Paul A Sigala · 2026 to 2026
$462k
American Heart Association 10.58275/aha.24pre1193935.pc.gr.190684National Institute of Allergy and Infectious Diseases R01AI125534National Institute of Allergy and Infectious Diseases T32AI055434NIAID NIH HHS R01 AI125534NIAID NIH HHS T32 AI055434NIDDK NIH HHS U54 DK110858NIDDK NIH HHS U54DK110858NIGMS NIH HHS R35 GM153408NIGMS NIH HHS R35GM153408NIGMS NIH HHS R35 GM161383NIGMS NIH HHS R35GM161383
6 · The paper itself

Abstract

Acyl carrier protein (ACP) and its 4-phosphopantetheine prosthetic group canonically function as the soluble scaffold for acyl chain assembly and elongation during type II fatty acid biosynthesis (FASII).

Indexed as

Acyl Carrier ProteinApicoplastsFatty AcidsPlasmodium falciparumProtozoan ProteinsHumansPyruvate KinaseAcyl Carrier ProteinFatty AcidsProtozoan ProteinsPyruvate Kinaseacyl carrier proteinapicoplastbiochemistrychemical biologyFASIIinfectious diseasemalaria parasitesmetabolic regulationmicrobiologyP. falciparumpyruvate kinase

Identifiers

PMID42735020
PMCPMC13574338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.