ArticleDrug delivery and translational research2026
Coptis chinensis -derived nanovesicle-loaded biodegradable hydrogel for preventing post-laminectomy epidural fibrosis.
Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Post-laminectomy epidural fibrosis (PLEF) is a major contributor to failed back surgery syndrome, yet current preventive strategies remain unsatisfactory. Here, we engineered an injectable, biodegradable methacrylated hyaluronic acid-phenylboronic acid (HAMA-PBA) hydrogel incorporating Coptis chinensis-derived nanovesicles (CCNVs) for localized PLEF prevention. Characterization confirmed the successful isolation of nanoscale CCNVs and their uniform three-dimensional distribution within the hydrogel matrix. In vitro, the CCNVs-loaded hydrogel significantly suppressed L929 fibroblast proliferation and migration, primarily by inhibiting the TGF-[Formula: see text]/Smad2 signaling pathway. In a rat laminectomy model, local application of the HAMA-PBA@CCNVs hydrogel markedly reduced epidural scar adhesion and fibrous tissue formation. Furthermore, systemic safety and excellent biocompatibility were confirmed across major organs. Overall, this CCNVs-loaded hydrogel provides a safe, targeted, and effective nanobiotechnology-based strategy to prevent post-surgical epidural fibrosis and improve spinal surgery outcomes.Clinical trial number: not applicable.
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