Evidence map›Paper›PMID 42734672›Full record

ArticleClinical oral investigations2026

Proteomic profile of the dentine pellicle modified with plant polyphenols and fluoride.

Thiago Saads Carvalho, Tommy Baumann, Marilia Afonso Rabelo Buzalaf, Daniela Rios, Matthias Hannig, Samira Helena Niemeyer

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Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thiago Saads CarvalhoDepartment of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Freiburgstrasse 7, Bern, CH 3010, Switzerland. thiago.saads@unibe.ch.ORCID https://orcid.org/0000-0002-2435-1169
Tommy BaumannDepartment of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Freiburgstrasse 7, Bern, CH 3010, Switzerland.ORCID http://orcid.org/0000-0002-5950-4137
Marilia Afonso Rabelo BuzalafDepartment of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.ORCID http://orcid.org/0000-0002-5985-3951
Daniela RiosDepartment of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.ORCID http://orcid.org/0000-0002-9162-3654
Matthias HannigClinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, Homburg, Germany.ORCID http://orcid.org/0000-0003-0570-7382
Samira Helena NiemeyerDepartment of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Freiburgstrasse 7, Bern, CH 3010, Switzerland.ORCID http://orcid.org/0000-0001-9023-908X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDespite its protective role, the dentine pellicle has rarely been studied, therefore we aimed to map out the proteomic profile of in vitro dentine pellicles before and after modification. MATERIALS AND

methodsA total of 135 human dentine specimens were prepared. After initial pellicle formation with 150 µl pooled human saliva (37 °C, 30 min), the dentine specimens were immersed in one of 9 pellicle modification solutions (2 ml/specimen): deionized water (non-modified pellicle), SnCl

resultsA total of 382 proteins were identified in all the proteomic analyses for all groups. Pellicle modification with fluoride, either NaF or SnCl

conclusionsWe conclude that NaF and SnCl CLINICAL RELEVANCE: Plant extract solutions with fluoride can significantly modify the proteomic structure of the dentine pellicle, which clarifies the mechanism of action of polyphenols on the protection of dentine demineralization.

Indexed as

Dental PellicleFluoridesPlant ExtractsPolyphenolsProteomicsChromatography, LiquidFluoride TreatmentHumansIn Vitro TechniquesSodium FluorideTandem Mass SpectrometryFluoridesPlant ExtractsPolyphenolsSodium FluorideDentine pellicleFluoridePellicle modification.Plant extractsPolyphenolsSaliva

Identifiers

PMID42734672
PMCPMC13574873

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.