Evidence map›Paper›PMID 42734462›Full record

ReviewMedical gas research2027

Medical gases and hypertensive disorders of pregnancy: therapeutic mechanisms and research advances.

Zhiguang Xu, Geng Tian, Di Zhou, Fuju Wu

Abstract readReview
In one paragraph

Review in Medical gas research, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhiguang XuDepartment of Gynecology and Obstetrics, The Second Hospital of Jilin University, Jilin University, Changchun, Jilin Province, China.ORCID 0009-0000-1295-650
Geng TianDepartment of Gynecology and Obstetrics, The Second Hospital of Jilin University, Jilin University, Changchun, Jilin Province, China.
Di ZhouDepartment of Ultrosound, The Second Hospital of Jilin University, Jilin University, Changchun, Jilin Province, China.
Fuju WuDepartment of Gynecology and Obstetrics, The Second Hospital of Jilin University, Jilin University, Changchun, Jilin Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertensive disorders during pregnancy pose a serious threat to the health of both mothers and infants, yet the range of available clinical treatments is limited. This review summarizes the mechanisms and recent advances in the use of medical gases, such as nitric oxide, hyperbaric oxygen, carbon monoxide and hydrogen sulfide, in the treatment of this condition. These gaseous molecules have unique protective effects, including regulating vascular tone, improving placental blood perfusion and inhibiting oxidative stress and inflammatory responses. However, their clinical application faces major challenges, including precise dose control, optimization of delivery methods and assessment of long-term safety. While this review suggests that medical gas therapy provides new avenues for research and potential applications in the management of hypertensive disorders of pregnancy, it also highlights the need for further basic and clinical studies to clarify their precise mechanisms.

Indexed as

GasesHypertension, Pregnancy-InducedAnimalsCarbon MonoxideFemaleHumansHydrogen SulfideHyperbaric OxygenationNitric OxideOxidative StressPregnancyCarbon MonoxideGasesHydrogen SulfideNitric Oxidecarbon monoxidehydrogen sulfidehyperbaric oxygenhypertensive disorders of pregnancymedical gasnitric oxideoxidative stressplacental perfusionpreeclampsiapreeclampsia pathophysiology

Identifiers

PMID42734462
PMCPMC13667357

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.