ReviewMedical gas research2027
Hydrogen therapy and cardiovascular diseases: a visualization analysis of research hotspots and application prospects.
Review in Medical gas research, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen, an emerging medical gas, has demonstrated diverse biological effects, including anti-oxidant, anti-inflammatory, and anti-apoptotic activities, offering significant therapeutic potential in cardiovascular diseases. This study aimed to explore the applications of hydrogen therapy in cardiovascular diseases and to illustrate both the current research status and future trends. 162 publications (129 original articles and 33 reviews) on hydrogen therapy in cardiovascular diseases were retrieved from the Web of Science Core Collection database up to April 9, 2025. The information was analyzed using Excel 2019, OriginPro 2024, VOSviewer 1.6.20 and CiteSpace 6.2. The number of publications on hydrogen therapy for cardiovascular diseases has shown a significant increase, with China, Japan, and the United States of America being the leading contributors. Keio University published the largest number of articles, and Sano Motoaki, the most prolific author (n = 14), is also from Keio University. Keyword clustering analysis shows that current research hotspots include "ischemia-reperfusion injury," "cardiac arrest," "oxidative stress," "inflammation," and "apoptosis," while emerging directions may focus on the "NLRP3 inflammasome," "pyroptosis," and "micro/nanomaterials." The underlying mechanisms of hydrogen therapy and its delivery approaches remain key research hotspots of hydrogen therapy for cardiovascular diseases; however, further high-quality clinical studies are needed to strengthen the evidence base and support its wider clinical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.