Evidence map›Paper›PMID 42734426›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Variable expressivity in long QT syndrome type 2 rabbits defines a low threshold for therapeutic

Nilufer N Turan, Allison Welton, Yichun Lu, Tae Yun Kim, Karim Roder, Elif Sengun, Anatoli Y Kabakov, Peter Bronk, Rebecca Martinez-Moreno, Brett Baggett and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Nilufer N TuranCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.ORCID 0000-0003-0710-1237
Allison WeltonCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.
Yichun LuCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.
Tae Yun KimCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.ORCID 0000-0003-0605-9575
Karim RoderCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.ORCID 0000-0003-1198-0449
Elif SengunCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.
Anatoli Y KabakovCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.
Peter BronkCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.
Rebecca Martinez-MorenoCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.
Brett BaggettCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.
Dennis TaiCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.
Derrick KangCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.ORCID 0009-0003-9856-5121
Matthew KilleenBioMarin Pharmaceutical Inc., Novato, California, United States.
Anne MerleyCenter for Animal Resources and Education, Brown University, Providence, Rhode Island, United States.
Susanna KurnickCenter for Animal Resources and Education, Brown University, Providence, Rhode Island, United States.
Lara HelwigCenter for Animal Resources and Education, Brown University, Providence, Rhode Island, United States.
Katja E OdeningDepartment of Cardiology and Angiology, University Heart Center Freiburg, University Medical Center Freiburg, Freiburg, Germany.ORCID 0000-0001-6999-841X
Bum-Rak ChoiCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.
Gideon KorenCardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University Health, Providence, Rhode Island, United States.

Funding

Gene therapy for long QT syndrome type 2R01HL166165 · NHLBI · RHODE ISLAND HOSPITAL · PI GIDEON KOREN · 2024 to 2026
$2.4M
BioMarin Pharmaceutical (BioMarin)HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL166165-01A1NHLBI NIH HHS R01 HL166165
6 · The paper itself

Abstract

Long QT syndrome type 2 (LQT2) is caused by pathogenic variants in the human

Indexed as

Ether-A-Go-Go Potassium ChannelsGenetic TherapyLong QT SyndromeMyocytes, CardiacAction PotentialsAnimalsAnimals, Genetically ModifiedComputer SimulationDisease Models, AnimalERG1 Potassium ChannelPhenotypeRabbitsERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsAAV9arrhythmiahERG potassium channelintravenous injectionlong QT syndrome 2

Identifiers

PMID42734426
PMCPMC13670150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.