ArticleBiomacromolecules2026
The Distinct Structural Propensities of Poly-C, A, and U Single-Stranded RNA.
Article in Biomacromolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Homopolymeric single-stranded RNAs (ssRNAs) are common biological motifs, yet their sequence-dependent solution structures remain incompletely defined. Particularly, rC30 and rA30 have not been characterized with atomic detail. Using optimized force fields, we integrate small-angle X-ray scattering (SAXS) with SAXS-driven molecular dynamics to generate and refine conformational ensembles for thirty-nucleotide-long strands of poly(rA), poly(rC), and poly(rU) (rA30, rC30, and rU30) in identical buffers. Scattering profiles are computed from refined MD-generated ensembles and accurately reproduce the SAXS measurements. Properties of these refined ensembles are further validated by circular dichroism (CD) and UV melting. Clear sequence-dependent order emerges: rA30 is the most compact and helical, rU30 is largely coil-like, and rC30 falls in between. Together, these cross-validated ensembles define distinct conformational propensities of ssRNA homopolymers, specifically highlighting poly(rC) as a unique, moderately structured, yet highly heterogeneous ssRNA. These findings may have implications for nucleotide-specific macromolecular recognition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.