ReviewCurrent drug research reviews2026
Method Development for Simultaneous Quantification of Anti-diabetic Drugs in Combined Solid Dosage Form: A Focus on Sulfonylureas, Biguanides, and Thiazolidinediones.
Review in Current drug research reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is a chronic metabolic disorder affecting millions worldwide, necessitating the effective management of blood glucose levels through anti-diabetic medications. Sulfonylureas and Biguanides, particularly Gliclazide, Glimepiride, Glipizide, Glibenclamide, and Metformin, are commonly used in combination therapies for improved glycemic control. Several methods, including UV spectrophotometry, high-performance liquid chromatography, high-performance thin-layer chromatography, micellar chromatography, and liquid chromatography-mass spectrometry, were assessed for their effectiveness. This study evaluates various analytical techniques employed to ensure the quality, efficacy, and safety of these formulations, under the ICH guidelines. RP-HPLC emerged as the most reliable technique, demonstrating superior sensitivity, precision, and linearity, with optimized retention times and low detection limits. LC-ESI-MS/MS exhibited the highest sensitivity, precision, and linearity, making it suitable for pharmacokinetic studies. Spectrophotometric and electrochemical methods provided cost-effective alternatives but lacked sensitivity. RP-HPLC and MS-based techniques can enhance data processing efficiency. These advancements will strengthen pharmaceutical quality control, ensure the safety and efficacy of anti-diabetic drug formulations, while optimizing therapeutic outcomes for diabetes management.
Indexed as
Identifiers
42734233What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.