Evidence map›Paper›PMID 42734183›Full record

ArticleGut microbes2026

Integrated metagenomic and metabolomic analysis identifies severity-specific inflammatory and metabolic signatures in post-stroke depression.

Wenyi Chen, Yawen Pan, Mengyuan Chen, Shanshan Zhou, Xiaodie Liu, Mengjiao Sun, Zixuan Yang, Yinghao Zhi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenyi ChenWenzhou Joint Training Base, Zhejiang Chinese Medical University, Wenzhou, China.
Yawen PanDepartment of Rehabilitation Medicine, The Second People's Hospital of Lishui, Lishui, China.
Mengyuan ChenDepartment of Rehabilitation Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, China.
Shanshan ZhouWenzhou Joint Training Base, Zhejiang Chinese Medical University, Wenzhou, China.
Xiaodie LiuWenzhou Joint Training Base, Zhejiang Chinese Medical University, Wenzhou, China.
Mengjiao SunWenzhou Joint Training Base, Zhejiang Chinese Medical University, Wenzhou, China.
Zixuan YangWenzhou Joint Training Base, Zhejiang Chinese Medical University, Wenzhou, China.
Yinghao ZhiDepartment of Rehabilitation Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, China.ORCID 0009-0004-9592-0121

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-stroke depression (PSD) is a common complication that significantly impacts patient prognosis. This study aimed to systematically characterize the associations among gut microbial ecology, metabolic profiles, and inflammatory responses across different severities of PSD. We conducted metagenomic sequencing, non-targeted metabolomics, and serum cytokine analysis (IL-1β, IL-6, IL-10, IL-18, TNF-

Indexed as

DepressionGastrointestinal MicrobiomeStrokeAgedBacteriaBiomarkersCytokinesDysbiosisFemaleHumansInflammationMaleMetabolomicsMetagenomicsMiddle AgedMultiomicsBiomarkersCytokinesbiomarkersgut microbiotainflammationmetabolomicsmulti-omics integrationPost-stroke depression

Identifiers

PMID42734183
PMCPMC13577261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.