Evidence map›Paper›PMID 42734180›Full record

ArticleEuropean journal of translational myology2026

Crack Dol

Luigi Meccariello, Predrag Grubor, Francesco Bosco, Claudio Domenico Cobisi, Lara Cristiano, Giuseppina Casolaro, Jacopo Conteduca, Giuseppe Rollo, Dimitra Melissaridou, Michele Mercurio and 3 more

Abstract read
In one paragraph

Article in European journal of translational myology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Luigi MeccarielloDepartment of Orthopedics and Traumatology, AORN San Pio Hospital, Benevento.ORCID 0000-0002-3669-189X
Predrag GruborCEO, School of Medicine and Surgery, University of Doboj.
Francesco BoscoDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy; Department of Orthopaedics and Traumatology, G.F. Ingrassia Hospital Unit, ASP 6, Palermo.
Claudio Domenico CobisiDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy; Department of Orthopaedics and Traumatology, G.F. Ingrassia Hospital Unit, ASP 6, Palermo.ORCID 0009-0001-2821-8015
Lara CristianoDiagnostic Imaging Unit, Studio Radiologico S. Domenico, A. Cristiano Co. S.r.l., Lamezia Terme, Italy; Department of Radiology, Paideia International Hospital, Rome.
Giuseppina CasolaroFinancial and Management Department, Azienda Sanitaria Locale (ASL) Benevento.
Jacopo ConteducaDepartment of Orthopaedic and Traumatology, Vito Fazzi Hospital, Lecce.ORCID 0000-0003-0798-2820
Giuseppe RolloDepartment of Orthopaedic and Traumatology, Vito Fazzi Hospital, Lecce.
Dimitra MelissaridouFirst department of orthopaedics,National and Kapodistrian University of Athens, Attikon University General Hospital.ORCID 0000-0003-4403-1100
Michele MercurioDepartment of Orthopedic and Trauma Surgery, "Magna Graecia" University, "Mater Domini" University Hospital, Catanzaro.ORCID 0000-0002-8742-5612
Lawrence CamardaDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo.
Fernando De MaioDepartment of Clinical Sciences and Translational Medicine, Section of Orthopaedic and Traumatology, University of Rome Tor Vergata, Roma.ORCID 0000-0002-5201-6755
Giuseppe RovereDepartment of Clinical Sciences and Translational Medicine, Section of Orthopaedic and Traumatology, University of Rome Tor Vergata, Roma, Italy; Department of Surgical Sciences, Policlinico Tor Vergata University Hospital, Rome.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative pain following patellar fracture surgery may delay rehabilitation and impair functional recovery. While cryotherapy is commonly used, concerns exist regarding its effects on local blood flow. Alternative topical cooling formulations may offer analgesic benefits without prolonged vasoconstriction. In this study, we compared postoperative pain, functional recovery, quality of life, and rescue analgesic consumption among patients receiving traditional ice therapy, ice spray, or Crack Dol® Foam Spray following surgical fixation of patellar fractures. Ninety patients undergoing surgical fixation for patellar fracture were prospectively enrolled in this non-randomized comparative cohort study and allocated into three groups (n=30 each) based on patient preference and clinical contraindications: ice therapy, ice spray, and Crack Dol® Foam Spray. Pain intensity (Visual Analogue Scale, VAS), health-related quality of life (SF-12), knee function (KOOS), and rescue analgesic consumption were assessed during postoperative follow-up. Patients in the Crack Dol® Foam Spray group had significantly lower VAS scores at 7, 30, and 90 days compared with the ice and ice spray groups (p=0.012, p=0.006, and p=0.004, respectively). At 90 days, SF-12 Physical and Mental Component Scores were significantly higher in the Crack Dol® group (p=0.009 and p=0.014, respectively). KOOS total scores were also significantly higher at 30 and 90 days (p=0.018 and p=0.007, respectively). Rescue analgesic consumption was significantly lower in the Crack Dol® group (p=0.011). In this prospective, non-randomized comparative cohort study, the use of Crack Dol® Foam Spray was associated with lower postoperative pain scores, lower rescue analgesic consumption, and better patient-reported functional and quality-of-life outcomes compared with traditional ice therapy and ice spray. Given the non-randomized treatment allocation, these findings should be interpreted as associations rather than evidence of a causal treatment effect. Further randomized controlled trials are needed to confirm these preliminary findings.

Indexed as

fractureIcemanagementoutcomespainpatella

Identifiers

PMID42734180
PMCPMC13688307

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.