Evidence map›Paper›PMID 42734097›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

High Adhesion Superoleophobic Oil Microdroplets to Create Ocular Hypertension In Vivo.

Eunji Hong, Dorcas Matuwana, Chen Lin, Mengwen Xiong, Sizhe Huang, Ruobai Xiao, Geunho Jang, Nicolle Gudiel Winter, Siyuan Rao, Qianbin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eunji Hong *Department of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York, USA.
Dorcas Matuwana *Department of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York, USA.
Chen LinDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York, USA.
Mengwen XiongDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York, USA.
Sizhe HuangDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York, USA.
Ruobai XiaoDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York, USA.
Geunho JangDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York, USA.
Nicolle Gudiel WinterCommonwealth Honors College, University of Massachusetts, Amherst, Massachusetts, USA.
Siyuan RaoDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York, USA.
Qianbin WangDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York, USA.ORCID https://orcid.org/0000-0002-9840-6732

Funding

Magnetic Modulation on Targeted Neural Circuits in AutismR00MH120279 · NIMH · UNIVERSITY OF MASSACHUSETTS AMHERST · PI RAO, SIYUAN · 2021 to 2023
$747k
Identifying Cellular Intraspinal Electrophysiological Features of "Spinal Shock"R21NS144777 · NINDS · STATE UNIVERSITY OF NY,BINGHAMTON · PI HE, ZHIGANG, RAO, SIYUAN · 2025 to 2025
$470k
Motion Adaptive Neural Interfaces for Brain-Body CommunicationF31NS151910 · NINDS · STATE UNIVERSITY OF NY,BINGHAMTON · PI Chen Lin · 2026 to 2026
$44k
Air Force Office of Scientific Research Young Investigator Program FA9550-23-1-0339Binghamton University S3IP Small Grant Awards ADLG 267Binghamton University S3IP Small Grant Awards ADLG274Binghamton University S3IP Small Grant Awards ADLG 324Binghamton University Watson College of Engineering and Applied Science Seed Grant Program 105383Brain & Behavior Research Foundation Young Investigator Grant 29878Craig H. Neilsen Foundation SCIRTS Pilot Research Grant 1348565National Science Foundation Faculty Early Career Development Program 2414753National Science Foundation Faculty Early Career Development Program 2442112NIH HHS F31NS151910NIH HHS R00MH120279NIH HHS R21NS144777NIMH NIH HHS R00 MH120279NINDS NIH HHS F31 NS151910NINDS NIH HHS R21 NS144777S.H. Ho Foundation Research Grants for Health Sciences and Technology, Faculty Startup Funds from Binghamton University, Binghamton University Transdisciplinary Areas of Excellence
6 · The paper itself

Abstract

Ocular hypertension is commonly linked with glaucomatous neurodegeneration. To investigate the mechanisms of glaucoma, in vivo models typically induce intraocular pressure elevation by obstructing aqueous humor flow in the trabecular meshwork. However, there is no satisfying in vivo model to maintain stable ocular hypertension and replicate neurodegenerative features accurately. Here, we introduce an injectable oil microdroplet model that achieves sustained IOP elevation and a 44.3% loss of retinal ganglion cells within four weeks in mice. The oil microdroplets exhibit an underwater "superoleophobic" state with high adhesion forces upon contact with tissue. Upon intracameral injection, the oil microdroplets deform and retain within various-sized trabecular architectures via a "self-locking" mechanism driven by differential Laplace pressures. Applying this oil microdroplet-induced mouse model, we observed an increase in nocturnal sleepiness, reflecting the increased daytime sleepiness observed in human glaucoma patients. This injectable oil microdroplet model provides a platform for studying glaucoma progression and evaluating potential therapeutic interventions.

Indexed as

glaucoma modelocular hypertensionoil microdropletsretinal ganglion cellssleep–wake regulation

Identifiers

PMID42734097
PMCPMC13602275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.