In one paragraphArticle in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
34 authors.
Eleni Dapergola *Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-University Würzburg, Germany (E.D., G.G.).ORCID 0009-0007-0673-5437 Marko Šustić *Department of Internal Medicine, Faculty of Medicine (M. Šustić), University of Rijeka, Croatia.
DiyaaElDin Ashour *Department of Internal Medicine I (D.E.D.A., E.T.M., U.H., S.F., G.C.R.), University Hospital Würzburg, Germany.ORCID 0000-0001-9924-0001 Ebram Tharwat MelikaDepartment of Internal Medicine I (D.E.D.A., E.T.M., U.H., S.F., G.C.R.), University Hospital Würzburg, Germany.
Maja Cokarić BrdovčakCenter for Proteomics, Faculty of Medicine (M.C.B., J.M.F., B.L., E.B., S.J., I.B.), University of Rijeka, Croatia.ORCID 0000-0002-9335-8700 Jelena Materljan FrankiCenter for Proteomics, Faculty of Medicine (M.C.B., J.M.F., B.L., E.B., S.J., I.B.), University of Rijeka, Croatia.ORCID 0000-0002-3209-9602 Berislav LisnićCenter for Proteomics, Faculty of Medicine (M.C.B., J.M.F., B.L., E.B., S.J., I.B.), University of Rijeka, Croatia.ORCID 0000-0002-3977-6004 Ema BellulovichCenter for Proteomics, Faculty of Medicine (M.C.B., J.M.F., B.L., E.B., S.J., I.B.), University of Rijeka, Croatia.ORCID 0009-0006-2091-9649 Valérie Boivin-JahnsInstitute of Pharmacology and Toxicology (V.B.-J.), University of Würzburg, Germany.ORCID 0000-0002-8547-4875 Tobias KrammerHelmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany (T.K., A.-E.S.).
Kenz Le GougeDivision of Cardiology, Department of Internal Medicine, University Heart Center, Medical University of Graz, Austria (K.L.G., L.R., P.P.R.).ORCID 0000-0003-4402-199X Lavinia RechDivision of Cardiology, Department of Internal Medicine, University Heart Center, Medical University of Graz, Austria (K.L.G., L.R., P.P.R.).ORCID 0000-0002-0787-446X Karl KashoferDiagnostic and Research Institute of Pathology, Diagnostic and Research Center of Molecular BioMedicine, Medical University of Graz (K.K.).ORCID 0000-0002-5803-4014 Peter P RainerDivision of Cardiology, Department of Internal Medicine, University Heart Center, Medical University of Graz, Austria (K.L.G., L.R., P.P.R.).ORCID 0000-0002-2840-6454 Roland JahnsInterdisciplinary Bank of Biomaterials and Data Würzburg (ibdw) (R.J.), University Hospital Würzburg, Germany.ORCID 0000-0003-2017-8191 Encarnita Mariotti-FerrandizImmunoregulation-Immunopathology-Immunotherapy, UMRS959, Sorbonne Université, INSERM, Paris, France (E.M.-F.).ORCID 0000-0002-8770-0186 Hamid MarwanComprehensive Heart Failure Center (D.E.D.A., E.T.M., H.M., M.T., M.K., U.H., S.F., G.C.R.), University Hospital Würzburg, Germany.ORCID 0000-0001-9849-6320 Maxim TerekhovComprehensive Heart Failure Center (D.E.D.A., E.T.M., H.M., M.T., M.K., U.H., S.F., G.C.R.), University Hospital Würzburg, Germany.ORCID 0000-0001-5617-7751 Mohammadreza KeshtkarComprehensive Heart Failure Center (D.E.D.A., E.T.M., H.M., M.T., M.K., U.H., S.F., G.C.R.), University Hospital Würzburg, Germany.ORCID 0009-0001-9665-9488 Antoine-Emmanuel SalibaHelmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Würzburg, Germany (T.K., A.-E.S.).ORCID 0000-0001-8539-2784 Panagiota ArampatziCore Unit Systems Medicine (P.A., M. Srivastava), University of Würzburg, Germany.ORCID 0000-0001-7925-8984 Mugdha SrivastavaCore Unit Systems Medicine (P.A., M. Srivastava), University of Würzburg, Germany.
Sven PleinLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom of Great Britain & Northern Ireland (S.P.).ORCID 0000-0002-0997-4384 Yasemin EkinciNewcastle University, Translational Research Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences (I.S., Y.E.).ORCID 0009-0007-6957-5506 Ioakim SpyridopoulosNewcastle University, Translational Research Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences (I.S., Y.E.).ORCID 0000-0002-2750-2444 Stipan JonjićCenter for Proteomics, Faculty of Medicine (M.C.B., J.M.F., B.L., E.B., S.J., I.B.), University of Rijeka, Croatia.ORCID 0000-0001-5003-3108 Ulrich HofmannDepartment of Internal Medicine I (D.E.D.A., E.T.M., U.H., S.F., G.C.R.), University Hospital Würzburg, Germany.ORCID 0000-0002-3681-2073 Stefan FrantzDepartment of Internal Medicine I (D.E.D.A., E.T.M., U.H., S.F., G.C.R.), University Hospital Würzburg, Germany.ORCID 0000-0002-0301-6185 Ilija BrizićCenter for Proteomics, Faculty of Medicine (M.C.B., J.M.F., B.L., E.B., S.J., I.B.), University of Rijeka, Croatia.ORCID 0000-0001-8839-7839 Georg GasteigerWürzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-University Würzburg, Germany (E.D., G.G.).ORCID 0000-0001-6986-127X Gustavo Campos RamosDepartment of Internal Medicine I (D.E.D.A., E.T.M., U.H., S.F., G.C.R.), University Hospital Würzburg, Germany.ORCID 0000-0001-9582-2725 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundEpidemiological studies have consistently associated cytomegalovirus (CMV) seropositivity with adverse cardiovascular outcomes. However, the mechanisms by which cytomegalovirus infection impacts pathophysiology in the heart remain poorly understood. In this study, we sought to dissect how latent murine cytomegalovirus infection impacts cardiac immune cell dynamics at steady-state and during postmyocardial infarction (MI) repair.
methodsExperimental MI studies were conducted in C57BL/6J mice previously infected with murine cytomegalovirus. In situ inflammatory responses were characterized by spectral flow cytometry, bulk and single-cell RNA/T-cell receptor (TCR) sequencing, whereas cardiac function was monitored by echocardiography and cardiac magnetic resonance imaging. Moreover, we retrospectively assessed the cytomegalovirus serostatus and associated T-cell expansions in a well-characterized patient cohort with longitudinal cardiac magnetic resonance imaging data available and performed bulk TCR sequencing on peripheral blood and myocardial samples to identify cytomegalovirus-specific TCRs.
resultsOur findings show that exposure to murine cytomegalovirus induces long-term changes in the cardiac transcriptional profile and alterations in various cardiac-resident immune cell populations, including the establishment of virus-specific memory CD8
conclusionsOur findings demonstrate that latent cytomegalovirus infection leads to long-term changes in the cardiac microenvironment, which ultimately impair post-MI healing outcomes.
Indexed as
CytomegalovirusCytomegalovirus InfectionsMuromegalovirusMyocardial InfarctionAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalFemaleHumansInflammationMaleMiceMice, Inbred C57BLMyocardiumcytomegalovirusepitopesflow cytometrymyocardial infarctionphenotype
Identifiers
PMID42734064
PMCPMC13649278
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