ArticleHypertension (Dallas, Tex. : 1979)2026
Relations of Menopause Timing With Pressure Pulsatility in the Framingham Study.
Amy Y Habib, Ross A Okazaki, Brenton R Prescott, Vanessa Xanthakis, Leroy L Cooper, Connie W Tsao, Emelia J Benjamin, Ramachandran S Vasan, Naomi M Hamburg, Gary F Mitchell
Abstract read
In one paragraphArticle in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Amy Y HabibEvans Department of Medicine, Boston Medical Center, MA (A.Y.H., R.A.O., E.J.B., N.M.H.).ORCID 0009-0008-2828-3029 Ross A OkazakiEvans Department of Medicine, Boston Medical Center, MA (A.Y.H., R.A.O., E.J.B., N.M.H.).ORCID 0009-0002-3513-4263 Brenton R PrescottSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, MA (B.R.P., V.X., R.S.V.).ORCID 0000-0002-3805-9070 Vanessa XanthakisSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, MA (B.R.P., V.X., R.S.V.).ORCID 0000-0002-7352-621X Connie W TsaoDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (C.W.T.).ORCID 0000-0003-3104-0681 Emelia J BenjaminEvans Department of Medicine, Boston Medical Center, MA (A.Y.H., R.A.O., E.J.B., N.M.H.).ORCID 0000-0003-4076-2336 Ramachandran S VasanSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, MA (B.R.P., V.X., R.S.V.).ORCID 0000-0001-7357-5970 Naomi M HamburgEvans Department of Medicine, Boston Medical Center, MA (A.Y.H., R.A.O., E.J.B., N.M.H.).ORCID 0000-0001-5504-5589 Funding
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8MCardiac microstructure and the immune-inflammatory response to SARS-CoV-2R01HL131532 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN, LI, DEBIAO · 2016 to 2025
$6.6MMediators of Systemic Inflammation and Heart Failure Risk in the CommunityR01HL143227 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2019 to 2022
$3.3MCAPSITE: Community Assessment of Pain and Sensitization in the ElderlyR01AG066010 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., EDWARDS, ROBERT R · 2020 to 2025
$3.3MVentricular-vascular coupling in the elderly: lifecourse determinants, trajectories, and prognostic significanceR01HL142983 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHENG, SUSAN, MITCHELL, GARY FRANK · 2019 to 2022
$3.2MEndothelial Cell Health Across the Spectrum of Cardiometabolic DiseaseR01HL168889 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Naomi Miriam Hamburg, Jennifer E Ho · 2023 to 2026
$3.1MMitochondrial Dynamics and UCP2 - Endothelial Dysfunction in Human ObesityR01HL115391 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM · 2013 to 2017
$2.8MVascular Stiffness as a Precursor of Hypertension in a Middle-aged CohortR01HL126136 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2015 to 2018
$2.6MAortic Dysfunction, Pulsatile Stress and Target Organ Damage in FraminghamR01HL107385 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2011 to 2014
$2.6MVascular Function in the Framingham Third GenerationR01HL070100 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2002 to 2005
$2.4MNHLBI NIH HHS 75N92019D00031NHLBI NIH HHS K01 HL161494NHLBI NIH HHS R01 HL070100NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL093328NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01 HL115391NHLBI NIH HHS R01 HL126136NHLBI NIH HHS R01 HL131532NHLBI NIH HHS R01 HL142983NHLBI NIH HHS R01 HL143227NHLBI NIH HHS R01 HL168889NHLBI NIH HHS U54 HL120163NIAMS NIH HHS K12 AR085635NIA NIH HHS R01 AG066010NIA NIH HHS R01 AG079390NIA NIH HHS RF1 AG079390NIDDK NIH HHS R01 DK080739
6 · The paper itselfAbstract
backgroundWomen have lower pulse pressure (PP) than men as young adults, but higher PP after a midlife PP nadir. This PP reversal is often attributed to lower estrogen levels at menopause. However, a detailed analysis of hemodynamic changes around the time of menopause has not been performed.
methodsRelations between the timing of menopause and sex differences in PP were assessed in the Framingham Heart Study cohorts (N=6760 unique participants) across 3 visits spanning 14 years. Women were categorized into 4 groups by age at menopause: persistently premenopausal or postmenopausal with early (<25th percentile, age <48 years), average (25th to 74th percentile, age 48-53), or late (≥75th percentile, age >53 years) menopause age.
resultsPP decreased with increasing age in women and men under 40 years of age, being lower in women than in men. PP increased with age in women and men after midlife and was higher in women than in men after age 60. Nadirs in midlife PP, adjusted for vascular risk factors, occurred at 47 years of age in men and at 39, 38, 37, and 37 years of age in the 4 menopause groups, respectively, with nadirs in the postmenopausal groups occurring an average of 6, 14, and 19 years before menopause.
conclusionsPP transitions from a falling to a rising profile approximately a decade earlier in women than in men, and up to 2 decades before the onset of menopause in women, suggesting that factors other than age of menopause are involved.
Indexed as
blood pressurecardiovascular diseasesestrogenrisk factorsvascular stiffness
Identifiers
PMID42734062
PMCPMC13576249
What OpenQuestion holds
Textmetadata
Read underepoch 390