Evidence map›Paper›PMID 42733896›Full record

ArticleMaterials today. Bio2026

Myocardial infarction treatment with a composite hydrogel containing metformin-induced vesicles of adipose-derived stem cells.

Jing Qi, Zhipeng Cao, Lu Yin, Hong Jin, Cheng Cheng, Xiaohong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing QiDepartment of Tissue Engineering, Center of 3D Printing & Organ Manufacturing, School of Intelligent Medicine, China Medical University (CMU), No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.
Zhipeng CaoDepartment of Forensic Pathology, School of Forensic Medicine, China Medical University, No. 77, Puhe Road, North New Area, Shenyang, Liaoning Province, 110122, China.
Lu YinDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110004, China.
Hong JinDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110004, China.
Cheng ChengDepartment of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110004, China.
Xiaohong WangDepartment of Tissue Engineering, Center of 3D Printing & Organ Manufacturing, School of Intelligent Medicine, China Medical University (CMU), No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI) leads to irreversible cardiomyocyte loss and adverse remodeling. Mesenchymal stem cell-derived extracellular vesicles (EVs) have shown promise in cardiac repair, but their clinical translation has been strictly limited by the short retention time and rapid clearance phenomena at the injury site. Metformin preconditioning of adipose-derived stem cells (ADSCs) is an effective way to enhance the yield of the EVs (Met-EVs). In this study, we incorporated Met-EVs into a composite hydrogel composed of decellularized extracellular matrices (dECMs) derived from porcine cardiac muscle and aortic adventitia, enabling sustained EV release and attenuation of inflammation after MI. In a rat MI model, the Met-EVs-laden dECM hydrogel (Met-EVs-dECM) significantly improved cardiac function recovery by enhancing cardiomyocyte survival, reducing cardiac apoptosis, and promoting angiogenesis. C1q/tumor necrosis factor-related protein 1 was identified as a contributor to the biological effects of Met-EVs, at least in part through the PI3K/AKT signaling pathway. Collectively, these findings demonstrate the therapeutic potential of the Met-EV-loaded dECM hydrogel for myocardial repair after MI.

Indexed as

ApoptosisC1q tumor necrosis factor-related protein 1Decellularized extracellular matrix (dECM)Extracellular vesicles (EVs)MetforminMyocardial infarction (MI)

Identifiers

PMID42733896
PMCPMC13571757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.