ArticleCureus2026
Beyond Chronic Rhinosinusitis: Multisystem Granulomatosis With Polyangiitis Presenting With Cavitary Pulmonary Nodules and Sinonasal Destruction.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Granulomatosis with polyangiitis (GPA) is a rare necrotizing vasculitis of small- to medium-sized vessels characterized by granulomatous inflammation, most commonly involving the upper respiratory tract, lungs, and kidneys. Early manifestations are frequently non-specific and may resemble chronic allergic or infectious rhinosinusitis, delaying recognition until destructive sinonasal, pulmonary, renal, neurologic, or cutaneous involvement emerges. Cutaneous vasculitis and cavitary pulmonary nodules further complicate the diagnostic process by raising concern for infection or malignancy. We report a 69-year-old woman with years of refractory nasal congestion and recurrent epistaxis who developed progressive sinonasal obstruction, septal perforation, palpable purpura, peripheral sensory symptoms, renal urinary abnormalities, and bilateral cavitary pulmonary nodules. Laboratory evaluation demonstrated PR3-ANCA/c-ANCA positivity, elevated inflammatory markers, anemia of inflammation, mild renal dysfunction, and urinalysis with proteinuria and microscopic hematuria. Computed tomography demonstrated destructive sinonasal disease and bilateral cavitary pulmonary nodules. Nasal biopsy showed necrotizing granulomatous inflammation with small to medium vessel vasculitis, confirming GPA. High-dose systemic glucocorticoids and rituximab-based induction therapy were initiated with
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