ArticleJournal of translational autoimmunity2026
Differential transcriptional and epigenetic signatures in CD4
Article in Journal of translational autoimmunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Juvenile idiopathic arthritis (JIA) is the most common musculoskeletal rheumatic disease affecting children. Following the currently used International League of Associations for Rheumatology (ILAR) classification, JIA encompasses seven clinically defined subtypes all of which share chronic inflammatory arthritis as a unifying symptom. Re-classification of JIA based on molecular signatures has been proposed and promises future patient stratification based on disease mechanisms and target-directed therapeutic interventions. This study applied flow cytometric immune cell profiling alongside mRNA expression analysis (NanoString inflammation panel) and DNA methylation profiling (Illumina EPIC450K arrays) to identify molecular signatures associated with enthesitis-related arthritis (ERA) or juvenile psoriatic arthritis (jPsA) subtypes of JIA. Disctinct gene expression and DNA methylation signatures in peripheral blood CD4
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