Evidence map›Paper›PMID 42733790›Full record

ArticleBioactive materials2027

Barcoded oligonucleotide system (BOLT) for targeted organ delivery.

Xucheng Hou, Changyue Yu, Yonger Xue, Yuwei Liu, Diana D Kang, Jeffrey L Bennett, Eliza Bliss-Moreau, Mi Ni, Yujie Liu, Gang Fang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xucheng HouIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Changyue YuIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yonger XueIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yuwei LiuIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Diana D KangIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jeffrey L BennettCalifornia National Primate Research Center, University of California Davis, Davis, CA, 95616, USA.
Eliza Bliss-MoreauCalifornia National Primate Research Center, University of California Davis, Davis, CA, 95616, USA.
Mi NiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Yujie LiuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Gang FangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ya Ying ZhengIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Siyu WangIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Meng TianIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yichen ZhongIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Haoyuan LiIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhengwei LiuIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dinglingge CaoIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yizhou DongIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The therapeutic potential of oligonucleotides (oligos) is limited by insufficient delivery to extrahepatic tissues. In vitro assays often fail to accurately predict in vivo behavior, while testing each oligo candidate in animals remains inherently low throughput. Here, we conceive a barcoded oligonucleotide system (BOLT), a platform that enables high-throughput in vivo evaluations of small-molecule ligands and identifies tissue-specific oligo delivery. BOLT integrates rational design of oligo barcodes, modular conjugation chemistry, and next-generation sequencing (NGS)-based quantification, allowing simultaneous evaluation of many chemically diverse ligand-oligo conjugates within a single animal. Notably, this platform is applicable in both mice and nonhuman primates (NHPs). Using BOLT, we discovered ligands with tropism for tissues such as the brain, lung, and muscle. Collectively, these results indicate that the BOLT platform can accelerate the discovery of tissue-targeting ligands for broad oligo therapeutics.

Identifiers

PMID42733790
PMCPMC13571527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.