Evidence map›Paper›PMID 42733769›Full record

ArticleMaterials today. Bio2026

CXCR4+ circulating tumor cells (CTCs) accumulate in subcutaneous, immune suppressive, CXCL12-loaded-hydrogel.

Luigi Portella, Dario Guido Di Febbraro, Dario Righelli, Giulia Bertolini, Giuseppe Guardascione, Giuseppina Rea, Crescenzo D'Alterio, Caterina Ieranò, Sara Santagata, Anna Maria Trotta and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Luigi PortellaMicroenvironment Molecular Targets, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Dario Guido Di FebbraroMicroenvironment Molecular Targets, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Dario RighelliDepartment of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy.
Giulia BertoliniUnit of Epigenomics and Biomarkers of Solid Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Giuseppe GuardascioneMicroenvironment Molecular Targets, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Giuseppina ReaMicroenvironment Molecular Targets, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Crescenzo D'AlterioMicroenvironment Molecular Targets, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Caterina IeranòMicroenvironment Molecular Targets, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Sara SantagataMicroenvironment Molecular Targets, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Anna Maria TrottaMicroenvironment Molecular Targets, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Marco GentiliUnit of Epigenomics and Biomarkers of Solid Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Roberta SulsentiUnit of Molecular Immunology, Department of Experimental Oncology Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Antonio LucianoExperimental Animal Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Giuseppe PalmaExperimental Animal Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Francesca BruzzeseExperimental Animal Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Ilaria Assunta ParisiCell Biology and Biotherapy, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Antonella De LucaCell Biology and Biotherapy, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
Luca RozUnit of Epigenomics and Biomarkers of Solid Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Roberto PacelliDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Stefania ScalaMicroenvironment Molecular Targets, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating tumor cells (CTCs) sensing the chemokine CXCL12 and invading hyaluronic acid hydrogel (CXCL12 loaded hydrogel, CLG) might display metastatic attitude. CLG recovered-human lung (H460, A549), and ovarian cancer cells (IGROV-1) overexpressed the CXCL12 receptor, CXCR4, developed larger spheres and activate transcriptional programs of invasion and stemness. Interestingly, CLG-U87 glioblastoma cells highly expressed EpCAM and significantly upregulated the very specific

Indexed as

CXCL12/CXCR4 axisHydrogelLung metastasisMacrophagesNeutrophils

Identifiers

PMID42733769
PMCPMC13571937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.