Evidence map›Paper›PMID 42733661›Full record

ArticleiScience2026

Altered striatal long-term potentiation in the eIF4E-TG mouse model of autism spectrum disorder.

Alina Aaltonen, Jone Razquin, Daniel R Garton, Julia Oyrer, Chiara Criscuolo, Ori J Lieberman, Eric Klann, Anders Borgkvist, Emanuela Santini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alina AaltonenDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Jone RazquinDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Daniel R GartonDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Julia OyrerDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Chiara CriscuoloDepartment of Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Ori J LiebermanDepartment of Neurology, University of California, San Francisco, CA, USA.
Eric KlannCenter for Neural Science, New York University, New York, NY, USA.
Anders BorgkvistDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Emanuela SantiniDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is associated with deficits in synaptic plasticity across multiple brain regions. While striatal dysfunction is observed in several ASD mouse models, the effects of ASD-associated genes on striatal plasticity remain poorly understood. We previously showed that overexpression of the Simons Foundation Autism Research Initiative (SFARI) ASD risk gene eukaryotic initiation factor 4E (

Indexed as

autism spectrum disorderdendritic spinesdopamineeIF4Elong-term potentiationNMDA receptorsspiny projection neuronsstriatumsynaptic plasticitytranslational control

Identifiers

PMID42733661
PMCPMC13571666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.