Evidence map›Paper›PMID 42733554›Full record

ArticleBioactive materials2027

Water-responsive injectable hydrogel achieving rapid in situ gelation and long-term colonic mucoadhesion for efficient fecal microbiota transplantation.

Zixin Chen, Yang Li, Wenxuan Xiong, Pengwei Ma, Weijie Liu, Hui Zhou, Xinglong Wang, Youchen Tang, Jian Cai, Mingli Su and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zixin ChenDepartment of General Surgery (Colorectal Surgery), Guangdong Institute of Gastroenterology, Biomedical Innovation Center, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, PR China.
Yang LiThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, PR China.
Wenxuan XiongDepartment of General Surgery (Colorectal Surgery), Guangdong Institute of Gastroenterology, Biomedical Innovation Center, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, PR China.
Pengwei MaPCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, PR China.
Weijie LiuPCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, PR China.
Hui ZhouPCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, PR China.
Xinglong WangPCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, PR China.
Youchen TangThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, PR China.
Jian CaiDepartment of Colorectal Surgery, The First Affiliated Hospital, Shenzhen University, Shenzhen Second People's Hospital, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen, 518035, PR China.
Mingli SuDepartment of General Surgery (Endoscopic Surgery), Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, Key Laboratory of Human Microbiome and Chronic Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, PR China.
Z ChenDepartment of General Surgery (Colorectal Surgery), Guangdong Institute of Gastroenterology, Biomedical Innovation Center, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, PR China.
W XiongDepartment of General Surgery (Colorectal Surgery), Guangdong Institute of Gastroenterology, Biomedical Innovation Center, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota dysbiosis is a critical factor in numerous diseases, yet current fecal microbiota (FM) transplantation therapies suffer from poor retention and inconsistent engraftment due to harsh gastric conditions or rapid clearance by bowel peristalsis. Herein, we report a thioester pre-crosslinked, low-viscosity injectable sol (Alg-NHS@αLA) formulated by directly mixing α-lipoic acid (αLA) and

Indexed as

Colonic retentionEndoscopic deliveryFecal microbiota transplantationHydrogelWater-triggered

Identifiers

PMID42733554
PMCPMC13571152

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.