Evidence map›Paper›PMID 42733546›Full record

ReviewInternet interventions2026

Modifiers of effectiveness and deterioration, and prognostic factors of adherence in internet-based interventions for treatment of perinatal depression: A systematic review and individual participant data meta-analysis.

Marketa Ciharova, Pim Cuijpers, Mathias Harrer, Yafit Hirshler, Olga-Maria Panagiotopoulou, Lingyao Tong, Clara Miguel, Iryna Frankova, Alan W Gemmill, Claudia Buntrock and 15 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internet interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Marketa CiharovaDepartment of Clinical, Neuro & Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Pim CuijpersDepartment of Clinical, Neuro & Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Mathias HarrerDepartment of Clinical, Neuro & Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Yafit HirshlerParent-Infant Research Institute, Heidelberg Repatriation Hospital, Heidelberg Heights, Australia.
Olga-Maria PanagiotopoulouDepartment of Clinical, Neuro & Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Lingyao TongDepartment of Clinical, Neuro & Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Clara MiguelDepartment of Clinical, Neuro & Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Iryna FrankovaDepartment of Clinical, Neuro & Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Alan W GemmillParent-Infant Research Institute, Heidelberg Repatriation Hospital, Heidelberg Heights, Australia.
Claudia BuntrockInstitute of Social Medicine and Health Systems Research, Medical Faculty, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Wouter van BallegooijenDepartment of Clinical, Neuro & Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Ana FonsecaUniversity of Coimbra, Center for Research in Neuropsychology and Cognitive-Behavioral Intervention, Coimbra, Portugal.
Mariana BranquinhoUniversity of Coimbra, Center for Research in Neuropsychology and Cognitive-Behavioral Intervention, Coimbra, Portugal.
Erik ForsellCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden.
Nicole E PughDepartment of Psychology, University of Regina, Regina, SK, Canada.
Heather D HadjistavropoulosDepartment of Psychology, University of Regina, Regina, SK, Canada.
Yaoyao SunPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Pamela FrancoSchool of Psychology, Pontificia Universidad Católica de Chile, Santiago, Chile.
Carlos Barquero-JiménezDepartment of Psychology, Universidad Loyola Andalucía, Spain.
Irene Gómez-GómezDepartment of Psychology, Universidad Loyola Andalucía, Spain.
Emma MotricoDepartment of Psychology, Universidad Loyola Andalucía, Spain.
Pedro Fonseca ZuccoloDepartamento de Psiquiatria, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.
Daniel FatoriLaboratório de Psicopatologia e Terapêutica Psiquiátrica LIM-23, Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
Jeannette MilgromParent-Infant Research Institute, Heidelberg Repatriation Hospital, Heidelberg Heights, Australia.
Eirini KaryotakiDepartment of Clinical, Neuro & Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Internet-based interventions for perinatal depression reduce depressive symptoms in new and expectant mothers. However, modifiers of their effects, and prognostic factors of adherence, are unknown. Objective: To assess modifiers of effectiveness and deterioration, and prognostic factors of adherence in internet-based interventions for perinatal depression. Methods: Systematic searches were conducted in three bibliographic databases on February 7, 2025. Two independent researchers identified randomized controlled trials (RCTs) of internet-based interventions for perinatal depression. We conducted conventional and two-stage individual participant data meta-analysis (IPDMA). Results: Eighteen studies were eligible, and data from nine ( Conclusions: Internet-based interventions for perinatal depression are effective for depressive and anxiety symptoms in new and expectant mothers. They may be offered to patients regardless of their age, education, relationship status, employment, baseline depressive or anxiety symptoms, previous treatment, number of children, or ethnic minority status, if they wish to follow them. RCTs should collect more information on factors relevant to the perinatal period, such as partner's mental health and pregnancy complications. Study registration: Open Science Framework (https://osf.io/98tms).

Indexed as

Blended interventionsGuided interventionsIndividual participant data meta-analysisInternet-based interventionsPerinatal depressionSelf-guided interventions

Identifiers

PMID42733546
PMCPMC13571255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.