Evidence map›Paper›PMID 42733494›Full record

ArticleiScience2026

Single nucleus transcriptomics reveals ITGA8-driven fibroblast remodeling in rheumatic valvular atrial fibrillation.

Jinjin Wu, Yuliang Wang, Weizhuo Liu, Zhengjie Wang, Jingjing Liu, Zikun Wang, Lei Yang, Lin Sun, Yilin Pan, Yangyang Sun and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Jinjin WuDepartment of Cardiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuliang WangThe First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Weizhuo LiuDepartment of Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhengjie WangDepartment of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China.
Jingjing LiuDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
Zikun WangDepartment of Cardiovascular Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lei YangDepartment of Vascular Surgery, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Lin SunDepartment of Cardiovascular Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yilin PanThe First Clinical Medical College of Nanjing Medical University, Nanjing, China.
Yangyang SunThe First Clinical Medical College of Nanjing Medical University, Nanjing, China.
Li ZhangShanghai Institute of Precision Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yongjun QianDepartment of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yangyang ZhangDepartment of Cardiovascular Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) associated with rheumatic valvular disease involves complex cellular remodeling of the atrial myocardium. Here, single-nucleus RNA sequencing of left atrial tissues from healthy donors and patients with persistent rheumatic valvular AF identified disease-associated transcriptional changes across major cardiac cell populations. Fibroblasts showed marked heterogeneity, with expansion of an ITGA8-enriched FB-C2-ELN state associated with extracellular matrix remodeling. Functional experiments demonstrated that ITGA8 promotes cardiac fibroblast proliferation, migration, and matrix production. In an ACh/CaCl2-induced rat model, fibroblast-targeted ITGA8 suppression reduced atrial fibrosis and AF susceptibility. These findings define cellular states associated with atrial remodeling and highlight fibroblast ITGA8 signaling as a regulator of fibrosis-related AF progression.

Indexed as

cardiac fibrosismacrophagesrheumatic valvular AF-associated remodelingsingle nucleus RNA-sequencing

Identifiers

PMID42733494
PMCPMC13571147

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.