Evidence map›Paper›PMID 42733488›Full record

ArticleBrain, behavior, & immunity - health2026

Sex and stress paradigm influence behavioural, neuroimmune, and microbiome responses in pubertal CD-1 mice.

Michaela Dworsky-Fried, Umar Haris Iqbal, Stéphane Bronner, Jérémie Auger, Olivier Mathieu, Noémie Auclair-Ouellet, Jacky Liang, Nafissa Ismail

Abstract read
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In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michaela Dworsky-FriedNISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ontario, K1N 6N5, Canada.
Umar Haris IqbalRosell Institute for Microbiome and Probiotics, Montreal, QC, H4P 2R2, Canada.
Stéphane BronnerRosell Institute for Microbiome and Probiotics, Montreal, QC, H4P 2R2, Canada.
Jérémie AugerRosell Institute for Microbiome and Probiotics, Montreal, QC, H4P 2R2, Canada.
Olivier MathieuRosell Institute for Microbiome and Probiotics, Montreal, QC, H4P 2R2, Canada.
Noémie Auclair-OuelletRosell Institute for Microbiome and Probiotics, Montreal, QC, H4P 2R2, Canada.
Jacky LiangNISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ontario, K1N 6N5, Canada.
Nafissa IsmailNISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ontario, K1N 6N5, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Puberty is a critical developmental period marked by heightened vulnerability to stress. Exposure to pubertal stress can have lasting effects on behaviour, immune function, and the gut-brain axis. The NLRP3 inflammasome and gut microbiome are key regulators of neuroinflammation, yet their roles across distinct pubertal stress paradigms remain unclear. This study compared behavioural, immune, and microbial outcomes in 100 CD-1 mice following chronic unpredictable stress (CUS; 14 or 28 days) or 7-day sleep disruption (SD) in pubertal males and females. Behavioural testing revealed stressor- and sex-specific effects: females spent more time in the open arms of the elevated plus maze, SD reduced open-arm exploration, 14-day CUS reduced centre activity in the open field, and SD increased immobility in the forced swim test. Plasma cytokines showed divergent patterns, with IL-22 elevated across stress conditions and IL-17A highest following 28-day CUS and in females overall. In the prefrontal cortex, SD males exhibited increased

Indexed as

Chronic stressGut-brain axisGut microbiomeNeuroinflammationNLRP3 inflammasomePuberty

Identifiers

PMID42733488
PMCPMC13571149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.